ArticleJournal of synchrotron radiation2013
A survey of global radiation damage to 15 different protein crystal types at room temperature: a new decay model.
Article in Journal of synchrotron radiation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Dose-dependent structural and electron-density features in the lytic polysaccharide monooxygenase NcAA9D.Acta crystallographica. Section D, Structural biology · 2026Article
- Damage-limited resolution for X-ray and electron microscopy of organic specimens.Acta crystallographica. Section D, Structural biology · 2026Article
- Radiation-induced peroxide rupture and its temperature-dependent repair probed by homogeneous X-ray irradiation.Acta crystallographica. Section D, Structural biology · 2026Article
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- Doses for X-ray and electron diffraction: New features in RADDOSE-3D including intensity decay models.Protein science : a publication of the Protein Society · 2024Article
- From femtoseconds to minutes: time-resolved macromolecular crystallography at XFELs and synchrotrons.Acta crystallographica. Section D, Structural biology · 2024Article
- Determining biomolecular structures near room temperature using X-ray crystallography: concepts, methods and future optimization.Acta crystallographica. Section D, Structural biology · 2023Article
- Slow protein dynamics probed by time-resolved oscillation crystallography at room temperature.IUCrJ · 2022Article
- Integrated sample-handling and mounting system for fixed-target serial synchrotron crystallography.Acta crystallographica. Section D, Structural biology · 2021Article
- Serial femtosecond and serial synchrotron crystallography can yield data of equivalent quality: A systematic comparison.Science advances · 2021Article
- High-resolution macromolecular crystallography at the FemtoMAX beamline with time-over-threshold photon detection.Journal of synchrotron radiation · 2021Article
- Radiation damage and dose limits in serial synchrotron crystallography at cryo- and room temperatures.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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- Article
- Bragg coherent diffraction imaging and metrics for radiation damage in protein micro-crystallography.Journal of synchrotron radiation · 2017Article
- Conformational variation of proteins at room temperature is not dominated by radiation damage.Journal of synchrotron radiation · 2017Article
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- In meso in situ serial X-ray crystallography of soluble and membrane proteins.Acta crystallographica. Section D, Biological crystallography · 2015Article
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4 authors.
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Abstract
The radiation damage rates to crystals of 15 model macromolecular structures were studied using an automated radiation sensitivity characterization procedure. The diffracted intensity variation with dose is described by a two-parameter model. This model includes a strong resolution-independent decay specific to room-temperature measurements along with a linear increase in overall Debye-Waller factors. An equivalent representation of sensitivity via a single parameter, normalized half-dose, is introduced. This parameter varies by an order of magnitude between the different structures studied. The data show a correlation of crystal radiation sensitivity with crystal solvent content but no dose-rate dependency was detected in the range 0.05-300 kGy s(-1). The results of the crystal characterization are suitable for either optimal planning of room-temperature data collection or in situ crystallization plate screening experiments.
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