ArticleIntegrative biology : quantitative biosciences from nano to macro2013
Dynamic deformability of Plasmodium falciparum-infected erythrocytes exposed to artesunate in vitro.
Article in Integrative biology : quantitative biosciences from nano to macro, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 3 citations in OpenAlex.
- Recent Advances of PDMS In Vitro Biomodels for Flow Visualizations and Measurements: From Macro to Nanoscale Applications.Micromachines · 2024Review
- Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Erythrocyte flow through the interendothelial slits of the splenic venous sinus.Biomechanics and modeling in mechanobiology · 2021Article
- Microfluidic-Based Biosensor for Sequential Measurement of Blood Pressure and RBC Aggregation Over Continuously Varying Blood Flows.Micromachines · 2019Article
- Biophysical phenotyping of cells via impedance spectroscopy in parallel cyclic deformability channels.Biomicrofluidics · 2019Article
- Collective behavior of red blood cells in confined channels.The European physical journal. E, Soft matter · 2019Article
- Article
- Methods to Investigate the Deformability of RBC During Malaria.Frontiers in physiology · 2019Review
- Deformation of Red Blood Cells, Air Bubbles, and Droplets in Microfluidic Devices: Flow Visualizations and Measurements.Micromachines · 2018Review
- Reduced red blood cell deformability inBlood advances · 2018Article
- Determination of red blood cell deformability using centrifugal force in a three-dimensional-printed mini-disk (3D-PMD).PloS one · 2018Article
- High-throughput and label-free parasitemia quantification and stage differentiation for malaria-infected red blood cells.Biosensors & bioelectronics · 2017Article
- Microfluidic Iterative Mechanical Characteristics (iMECH) Analyzer for Single-Cell Metastatic Identification.Analytical methods : advancing methods and applications · 2017Article
- Simultaneous measurement of erythrocyte deformability and blood viscoelasticity using micropillars and co-flowing streams under pulsatile blood flows.Biomicrofluidics · 2017Article
- Article
- Article
- Study of individual erythrocyte deformability susceptibility to INFeD and ethanol using a microfluidic chip.Scientific reports · 2016Article
- The mechanical properties of stored red blood cells measured by a convenient microfluidic approach combining with mathematic model.Biomicrofluidics · 2016Article
- Reduced deformability of parasitized red blood cells as a biomarker for anti-malarial drug efficacy.Malaria journal · 2015Article
- Towards microfluidic-based depletion of stiff and fragile human red cells that accumulate during blood storage.Lab on a chip · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Artesunate (ART) is widely used for the treatment of malaria, but the mechanisms of its effects on parasitized red blood cells (RBCs) are not fully understood. We investigated ART's influence on the dynamic deformability of ring-stage Plasmodium falciparum infected red blood cells (iRBCs) in order to elucidate its role in cellular mechanobiology. The dynamic deformability of RBCs was measured by passing them through a microfluidic device with repeated bottleneck structures. The quasi-static deformability measurement was performed using micropipette aspiration. After ART treatment, microfluidic experiments showed 50% decrease in iRBC transit velocity whereas only small (~10%) velocity reduction was observed among uninfected RBCs (uRBCs). Micropipette aspiration also revealed ART-induced stiffening in RBC membranes. These results demonstrate, for the first time, that ART reduces the dynamic and quasi-static RBC deformability, which may subsequently influence blood circulation through the microvasculature and spleen cordal meshwork, thus adding a new aspect to artesunate's mechanism of action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.