ArticleThe ISME journal2013
Members of native coral microbiota inhibit glycosidases and thwart colonization of coral mucus by an opportunistic pathogen.
Article in The ISME journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 84 citations in OpenAlex.
- Distinct Host-Specific Bacterial Assemblages in Four CongenericMicroorganisms · 2025Article
- Probiotics prevent mortality of thermal-sensitive corals exposed to short-term heat stress.ISME communications · 2025Article
- Influence of reef habitat on coral microbial associations.Environmental microbiology reports · 2024Article
- The coral microbiome in sickness, in health and in a changing world.Nature reviews. Microbiology · 2024Review
- Article
- Coral and Seawater Metagenomes Reveal Key Microbial Functions to Coral Health and Ecosystem Functioning Shaped at Reef Scale.Microbial ecology · 2023Article
- Antibiotic Activity Altered by Competitive Interactions Between Two Coral Reef-Associated Bacteria.Microbial ecology · 2023Article
- Greater functional diversity and redundancy of coral endolithic microbiomes align with lower coral bleaching susceptibility.The ISME journal · 2022Article
- The coral pathogen Vibrio coralliilyticus kills non-pathogenic holobiont competitors by triggering prophage induction.Nature ecology & evolution · 2022Article
- Coral mucus rapidly induces chemokinesis and genome-wide transcriptional shifts toward early pathogenesis in a bacterial coral pathogen.The ISME journal · 2021Article
- Friends or Foes-Microbial Interactions in Nature.Biology · 2021Review
- Parasitic 'Candidatus Aquarickettsia rohweri' is a marker of disease susceptibility in Acropora cervicornis but is lost during thermal stress.Environmental microbiology · 2020Article
- Article
- Defining Coral Bleaching as a Microbial Dysbiosis within the Coral Holobiont.Microorganisms · 2020Review
- Exceptional but vulnerable microbial diversity in coral reef animal surface microbiomes.Proceedings. Biological sciences · 2020Article
- Article
- Inhibitors of Bacterial Swarming Behavior.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Review
- Coral microbiome dynamics, functions and design in a changing world.Nature reviews. Microbiology · 2019Review
- Skin microbiome of coral reef fish is highly variable and driven by host phylogeny and diet.Microbiome · 2018Article
- Disruption of skin microbiota contributes to salamander disease.Proceedings. Biological sciences · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The outcome of the interactions between native commensal microorganisms and opportunistic pathogens is crucial to the health of the coral holobiont. During the establishment within the coral surface mucus layer, opportunistic pathogens, including a white pox pathogen Serratia marcescens PDL100, compete with native bacteria for available nutrients. Both commensals and pathogens employ glycosidases and N-acetyl-glucosaminidase to utilize components of coral mucus. This study tested the hypothesis that specific glycosidases were critical for the growth of S. marcescens on mucus and that their inhibition by native coral microbiota reduces fitness of the pathogen. Consistent with this hypothesis, a S. marcescens transposon mutant with reduced glycosidase and N-acetyl-glucosaminidase activities was unable to compete with the wild type on the mucus of the host coral Acropora palmata, although it was at least as competitive as the wild type on a minimal medium with glycerol and casamino acids. Virulence of the mutant was modestly reduced in the Aiptasia model. A survey revealed that ∼8% of culturable coral commensal bacteria have the ability to inhibit glycosidases in the pathogen. A small molecular weight, ethanol-soluble substance(s) produced by the coral commensal Exiguobacterium sp. was capable of the inhibition of the induction of catabolic enzymes in S. marcescens. This inhibition was in part responsible for the 10-100-fold reduction in the ability of the pathogen to grow on coral mucus. These results provide insight into potential mechanisms of commensal interference with early colonization and infection behaviors in opportunistic pathogens and highlight an important function for the native microbiota in coral health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.