Evidence map›Paper›PMID 23254450›Full record

ArticleJournal of cellular physiology2013

Growth of v-src-transformed cells in serum-free medium through the induction of growth factors.

Tiziana Deangelis, Andrew Quong, Andrea Morrione, Renato Baserga

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tiziana DeangelisDepartment of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Andrew Quong
Andrea Morrione
Renato Baserga
Sidney Kimmel Cancer Center · USThomas Jefferson University · US

Funding

Progranulin signaling in bladder cancerR01CA164462 · NCI · THOMAS JEFFERSON UNIVERSITY · PI IOZZO, RENATO V., MORRIONE, ANDREA · 2012 to 2016
$1.6M
NCI NIH HHS CA164462NCI NIH HHS R01 CA164462
6 · The paper itself

Abstract

The v-src oncogene is one of only two oncogenes capable of transforming mouse embryo fibroblasts (MEFs) lacking the IGF-IR gene (R-cells). R-/v-src cells grow robustly in the absence of serum, suggesting the hypothesis that they may produce one or more growth factors that would sustain their ability to proliferate in serum-free condition. Using proteomic approaches on serum-free conditioned media derived from v-src-transformed cells, we have identified two growth promoting factors: ostepontin and proliferin. Subsequent experiments have indicated that osteopontin plays a prevalent role in promoting growth of v-src-transformed cells in serum-deprived condition.

Indexed as

Genes, srcAnimalsCell LineCell Transformation, NeoplasticCulture Media, Serum-FreeGene Knockdown TechniquesGlycoproteinsIntercellular Signaling Peptides and ProteinsMiceOsteopontinProlactinProteomicsReceptor, IGF Type 1Signal TransductionCulture Media, Serum-FreeGlycoproteinsIntercellular Signaling Peptides and ProteinsOsteopontinPrl2c2 protein, mouseProlactinReceptor, IGF Type 1Spp1 protein, mouse

Identifiers

PMID23254450
PMCPMC4062974
OpenAlexW2021683047

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.