ArticleNeuroscience research2013
Probing the function of neuronal populations: combining micromirror-based optogenetic photostimulation with voltage-sensitive dye imaging.
Article in Neuroscience research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Early-life prefrontal cortex inhibition and early-life stress lead to long-lasting behavioral, transcriptional, and physiological impairments.Molecular psychiatry · 2024Article
- Optogenetically Engineered Neurons Differentiated from Human SH-SY5Y Cells Survived and Expressed ChR2 in 3D Hydrogel.Biomedicines · 2022Article
- Bioengineered optogenetic model of human neuromuscular junction.Biomaterials · 2021Article
- The Optogenetic Revolution in Cerebellar Investigations.International journal of molecular sciences · 2020Review
- All-optical crosstalk-free manipulation and readout of Chronos-expressing neurons.Journal of physics D: Applied physics · 2019Article
- Optical interrogation of neuronal circuitry in zebrafish using genetically encoded voltage indicators.Scientific reports · 2018Article
- Digital micromirror based near-infrared illumination system for plasmonic photothermal neuromodulation.Biomedical optics express · 2017Article
- Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels.eLife · 2016Article
- Scattering of Sculpted Light in Intact Brain Tissue, with implications for Optogenetics.Scientific reports · 2015Article
- All-optical mapping of barrel cortex circuits based on simultaneous voltage-sensitive dye imaging and channelrhodopsin-mediated photostimulation.Neurophotonics · 2015Article
- Combining Membrane Potential Imaging with Other Optical Techniques.Advances in experimental medicine and biology · 2015Review
- Patterned optogenetic modulation of neurovascular and metabolic signals.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Imaging GFP-based reporters in neurons with multiwavelength optogenetic control.Biophysical journal · 2014Article
- All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins.Nature methods · 2014Article
- Precise control of movement kinematics by optogenetic inhibition of Purkinje cell activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Combined optogenetics and voltage sensitive dye imaging at single cell resolution.Frontiers in cellular neuroscience · 2014Article
- A toolbox for spatiotemporal analysis of voltage-sensitive dye imaging data in brain slices.PloS one · 2014Article
- Characterization of a highly efficient blue-shifted channelrhodopsin from the marine alga Platymonas subcordiformis.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Recent advances in our understanding of brain function have come from using light to either control or image neuronal activity. Here we describe an approach that combines both techniques: a micromirror array is used to photostimulate populations of presynaptic neurons expressing channelrhodopsin-2, while a red-shifted voltage-sensitive dye allows optical detection of resulting postsynaptic activity. Such technology allowed us to control the activity of cerebellar interneurons while simultaneously recording inhibitory responses in multiple Purkinje neurons, their postsynaptic targets. This approach should substantially accelerate our understanding of information processing by populations of neurons within brain circuits.
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Registered trials
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