Evidence map›Paper›PMID 23254191›Full record

ReviewNature reviews. Neuroscience2013

Neurotrophin regulation of neural circuit development and function.

Hyungju Park, Mu-ming Poo

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01870518 (Neurocognitive Effects of Bilateral Subthalamic Nucleus Versus Globus Pallidus Interna Deep Brain Stimulation in Parkinson's Disease Patients With Mild Cognitive Impairment), which is not on this map. Cited by 1,054 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,054citing papers in PubMed, 6 pooled it
34.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01870518 naterminatednot on this map

Neurocognitive Effects of Bilateral Subthalamic Nucleus Versus Globus Pallidus Interna Deep Brain Stimulation in Parkinson's Disease Patients With Mild Cognitive Impairment

TypeinterventionalSponsorSt. Joseph's Hospital and Medical Center, PhoenixRan2013 to 2016Enrolled13ConditionsParkinson's Disease, Mild Cognitive Impairment, DementiaArmsBilateral GPi DBS, Bilateral STN DBS
3 · Its place in the literature

Who cites it

1,054 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,950 citations in OpenAlex.

  1. Pooled it
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  11. Enhancement of hippocampal synaptic AMPA receptor function by the antidepressant tianeptine and by opioid peptides.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Article
  13. Glutamine metabolism in health and disease.Signal transduction and targeted therapy · 2026
    Review
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994 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hyungju ParkDivision of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA.
Mu-ming Poo
University of California, Berkeley · US

Funding

Spike Timing-Dependent Plasticity of Neural CircuitsR01NS036999 · NINDS · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI POO, MU-MING · 1998 to 2015
$3.8M
Development and Plasticity of a Retinotectal SystemR01EY014979 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI POO, MU-MING · 2003 to 2012
$2.7M
NEI NIH HHS EY014979NINDS NIH HHS NS 036999
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.

Indexed as

BrainAnimalsBrain-Derived Neurotrophic FactorHumansNerve NetNeuronsSynapsesBrain-Derived Neurotrophic Factor

Identifiers

PMID23254191
OpenAlexW2109309568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.