ArticleClinical and translational allergy2012
Exploring the temporal development of childhood IgE profiles to allergen components.
Article in Clinical and translational allergy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Food-sensitized children with juvenile colorectal polyps exhibit a distinct mucosal and fecal microbial signature associated with inflammation.Scientific reports · 2026Article
- Integrated nasopharyngeal airway metagenome and asthma genetic risk endotyping of severe bronchiolitis in infancy and risk of childhood asthma.The European respiratory journal · 2024Article
- Early-life exposure to residential greenness and risk of asthma in a U.S. bronchiolitis cohort.Allergy · 2024Article
- Allergic sensitization to lipocalins reflects asthma morbidity in dog dander sensitized children.Clinical and translational allergy · 2022Article
- Patterns of sensitization to inhalant and food allergens among pediatric patients from the Moscow region (Russian Federation).PloS one · 2018Article
- Evaluation of a novel automated allergy microarray platform compared with three other allergy test methods.Clinical and experimental immunology · 2016Article
- The use of the MeDALL-chip to assess IgE sensitization: a new diagnostic tool for allergic disease?Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2015Article
- ELISA in the multiplex era: potentials and pitfalls.Proteomics. Clinical applications · 2015Review
- Advances in allergen-microarray technology for diagnosis and monitoring of allergy: the MeDALL allergen-chip.Methods (San Diego, Calif.) · 2014Article
- A WAO - ARIA - GA²LEN consensus document on molecular-based allergy diagnostics.The World Allergy Organization journal · 2013Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
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backgroundChildren often develop allergies that may or not persist into adulthood. Although the different allergic symptoms over time have been well documented, the underlying pattern of sensitization to various proteins and subsequent allergy development is unexplored.The aim was to study the sensitization pattern to allergen components over time from infancy to adulthood in a group of infants with heredity for allergic diseases.
methodsIgE profiles were monitored in a group of 67 children from 6 months to 18 years using a microarray chip (ImmunoCAP® ISAC) containing 103 allergen components derived from 47 allergen sources. The chip IgE profile was compared with clinical history, skin prick test results and diagnoses (atopic dermatitis, asthma and allergic rhinoconjunctivitis) at each time point for each child.
resultsIgE profiles were unique for each child and showed broad agreement with the results of skin prick tests and doctors' diagnoses. In addition, close examination of the IgE profiles often revealed early indication of subsequent allergies. IgE profiles also facilitated the examination of cross-reactivity contra co-sensitization, thereby greatly enhancing the possibility for managing patients.
conclusionThis explorative description indicates that sensitization pattern to allergen components differs over time as well as among allergic individuals when examined with microarray technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.