ArticleClinical and translational science2012
Distinctive frequencies of +874T/A IFN-γ gene polymorphism in a healthy Serbian population.
Article in Clinical and translational science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The cytokine polymorphisms affecting Th1/Th2 increase the susceptibility to, and severity of, chronic ITP.BMC immunology · 2017Article
- TNF, IL12B, and IFNG Gene Polymorphisms in Serbian Patients with Psoriasis.Annals of dermatology · 2015Article
- Single nucleotide polymorphisms in the interferon gamma gene are associated with distinct types of retinochoroidal scar lesions presumably caused by Toxoplasma gondii infection.Memorias do Instituto Oswaldo Cruz · 2014Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSingle nucleotide polymorphism (SNP) in IFN-γ gene (+874T/A) that determines high (TT), low (AA), and intermediate (TA) responder phenotypes has shown associations with susceptibility to infectious and chronic inflammatory diseases, as well as disease outcome. Therefore, the susceptibility to and outcome of certain diseases can vary in different ethnic populations partially due to the notable differences in frequencies of genotypes and alleles between them. The aim of this study was to determine the distribution of +874T/A genotype and allele frequencies in a healthy Serbian population as a reference for further disease association studies. MATERIALS AND
methodsGenomic DNA samples from 166 healthy volunteers were evaluated for IFN-γ SNP at position +874 using TaqMan SNP genotyping assay.
resultsThe frequencies of AA, AT, and TT genotypes were 28.9%, 49.4%, and 21.7%, respectively. The A and T allele frequencies were 53.6% and 46.4%.
conclusionsAnalysis of genotype and allele frequencies for IFN-γ+874T/A SNP in healthy subjects revealed, for the first time, the genetic profile for this polymorphism in a Serbian population resembling most European populations, but differing from some Asian and African ethnic groups.
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