ArticleIndian heart journal
Polymorphism of ACE gene as the genetic predisposition of coronary artery disease in Eastern India.
Article in Indian heart journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Effects of Common Polymorphisms in the MTHFR and ACE Genes on Diabetic Peripheral Neuropathy Progression: a Meta-Analysis.Molecular neurobiology · 2017Pooled it
- The role of angiotensin I-converting enzyme gene polymorphism and global DNA methylation in the negative associations between urine di-(2-ethylhexyl) phthalate metabolites and serum adiponectin in a young Taiwanese population.Clinical epigenetics · 2023Article
- Association of ACE I/D gene polymorphism and related risk factors in impaired fasting glucose and type 2 diabetes: a study among two tribal populations of North-East India.Molecular biology reports · 2022Article
- Role of Angiotensin-Converting Enzyme (ACE) gene polymorphism and ACE activity in predicting outcome after acute myocardial infarction.International journal of cardiology. Heart & vasculature · 2021Article
- Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism Is Not Responsible for Antihypertensive Therapy Induced New Onset of Type 2 Diabetes in Essential Hypertension.Clinical medicine insights. Endocrinology and diabetes · 2019Article
- Biomarkers for cognitive decline in patients with diabetes mellitus: evidence from clinical studies.Oncotarget · 2018Article
- Whole-Exomes Sequencing Delineates Gene Variants Profile in a Young Saudi Male with Familial Hypercholesterolemia: Case Report.Journal of clinical and diagnostic research : JCDR · 2017Article
- Influence of Angiotensin-Converting-Enzyme Gene Polymorphism on Echocardiographic Data of Patients with Ischemic Heart Failure.Arquivos brasileiros de cardiologia · 2016Observational
- Association of Increased Serum ACE Activity with Logical Memory Ability in Type 2 Diabetic Patients with Mild Cognitive Impairment.Frontiers in behavioral neuroscience · 2016Article
- Association of Angiotensin converting enzyme gene insertion / deletion polymorphism with risk of ischemic heart disease in a population of smokers in southern India.Journal of clinical and diagnostic research : JCDR · 2015Article
- Identifying Common Genetic Risk Factors of Diabetic Neuropathies.Frontiers in endocrinology · 2015Review
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- Association of polymorphisms in angiotensin-converting enzyme gene with gestational diabetes mellitus in Indian women.International journal of applied & basic medical researchArticle
- Q192R polymorphism in the PON1 gene and familial hypercholesterolemia in a Saudi population.Annals of Saudi medicineArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimA case control study was designed to assess whether the prevalence of ACE gene polymorphism has any role in the development of CAD.
methodsThe study included unrelated 217 cases with CAD and 255 healthy controls. PCR was done using primers followed by agarose gel electrophoresis for study of different ACE gene polymorphisms. Multiple logistic regression analysis was carried out to find association between studied genotypes and lifestyle as well as biochemical risk factors.
resultsBoth DD [OR: 2.16; 95%CI: (60.60-67.40)] and ID [OR: 1.48; 95%CI: (93.28-97.72)] genotypes of the ACE gene showed significant associations in the development of CAD. Coexistence of diabetes and hypertension found to be risk modifier of the disease. Tobacco intake in various forms elevates the risk of the disease among the cases with risk genotypes.
conclusionID and DD genotypes of ACE gene came out to be predisposing factors for the CAD cases in our study population.
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