Evidence map›Paper›PMID 23253299›Full record

ReviewMolecular oral microbiology2013

Microbial interactions in building of communities.

C J Wright, L H Burns, A A Jack, C R Back, L C Dutton, A H Nobbs, R J Lamont, H F Jenkinson

Abstract readReview
In one paragraph

Review in Molecular oral microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Quorum sensing inFrontiers in oral health · 2025
    Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Dynamic coexistence driven by physiological transitions in microbial communities.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Article
  9. From Global to Nano: A Geographical Perspective ofPathogens (Basel, Switzerland) · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. AmSystems · 2024
    Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

C J WrightDepartment of Oral Health and Systemic Disease, University of Louisville, Louisville, KY 40202, USA.
L H Burns
A A Jack
C R Back
L C Dutton
A H Nobbs
R J Lamont
H F Jenkinson

Funding

MOLECULAR ASPECTS OF ORAL PLAQUE FORMATIONR01DE012505 · NIDCR · UNIVERSITY OF WASHINGTON · PI Richard J Lamont, JAN S POTEMPA · 1998 to 2026
$9.5M
P GINGIVALIS INTERACTIONS WITH GINGIVAL EPITHELIAL CELLSR01DE011111 · NIDCR · UNIVERSITY OF WASHINGTON · PI HARIBABU BODDULURI, Richard J Lamont · 1995 to 2026
$5.4M
Intra-and interspecies communication in oral bacteriaR01DE014605 · NIDCR · UNIVERSITY OF LOUISVILLE · PI URIARTE, SILVIA M · 2003 to 2018
$5.3M
Streptococcus-Candida Communication in Oral BiofilmsR01DE016690 · NIDCR · UNIVERSITY OF BRISTOL · PI JENKINSON, HOWARD F, LAMONT, RICHARD J · 2006 to 2016
$3.8M
Proteomics of Porphyromonas gingivalis interactions with Fusobacterium nucleatumR01DE014372 · NIDCR · UNIVERSITY OF WASHINGTON · PI HACKETT, MURRAY · 2003 to 2014
$3.7M
P.gingivalis Interactions with Gingival Epithelial CellsR37DE011111 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2009 to 2018
$3.6M
Role of JAKs in innate responses to P. gingivalisR01DE017921 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2010 to 2019
$3.3M
Pathogenic mechanisms of F. alocisR21DE022867 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2012 to 2013
$404k
NIDCR NIH HHS DE11111NIDCR NIH HHS DE12505NIDCR NIH HHS DE16690NIDCR NIH HHS DE17921NIDCR NIH HHS DE22867NIDCR NIH HHS R01 DE011111NIDCR NIH HHS R01 DE012505NIDCR NIH HHS R01 DE014372NIDCR NIH HHS R01 DE014605NIDCR NIH HHS R01 DE016690NIDCR NIH HHS R01 DE017921NIDCR NIH HHS R21 DE022867NIDCR NIH HHS R37 DE011111Wellcome TrustWellcome Trust 097285
6 · The paper itself

Abstract

Establishment of a community is considered to be essential for microbial growth and survival in the human oral cavity. Biofilm communities have increased resilience to physical forces, antimicrobial agents and nutritional variations. Specific cell-to-cell adherence processes, mediated by adhesin-receptor pairings on respective microbial surfaces, are able to direct community development. These interactions co-localize species in mutually beneficial relationships, such as streptococci, veillonellae, Porphyromonas gingivalis and Candida albicans. In transition from the planktonic mode of growth to a biofilm community, microorganisms undergo major transcriptional and proteomic changes. These occur in response to sensing of diffusible signals, such as autoinducer molecules, and to contact with host tissues or other microbial cells. Underpinning many of these processes are intracellular phosphorylation events that regulate a large number of microbial interactions relevant to community formation and development.

Indexed as

BiofilmsCandida albicansHumansMicrobial ConsortiaMicrobial InteractionsMicrobial ViabilityMouthPorphyromonas gingivalisProteomeQuorum SensingStreptococcusTranscriptomeProteome

Identifiers

PMID23253299
PMCPMC3600090

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.