Trial reportWorld journal of surgical oncology2012
Collagen sealant patch to reduce lymphatic drainage after lymph node dissection.
Trial report in World journal of surgical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- The effect of fibrin glue on the postoperative lymphatic leakage after D2-lymphadenectomy and gastrectomy in patients with gastric cancer.BMC surgery · 2021Trial
- Comparison of TachoSil and TachoComb in patients undergoing liver resection-a randomized, double-blind, non-inferiority trial.Langenbeck's archives of surgery · 2017Trial
- Impact of the Ultrasonic scalpel on the amount of drained lymph after axillary or inguinal lymphadenectomy.BMC surgery · 2017Trial
- Does Suction Strategy Using a Negative-Pressure Wound Therapy System at the Extended Latissimus Dorsi Flap Donor Site After Breast Reconstruction Contribute to a Reduction in Seroma Formation?Aesthetic plastic surgery · 2026Article
- Effectiveness of TachoSil as Sealant in Lymphatic Leakage of Breast Cancer With Axillary Dissection.International journal of breast cancer · 2024Article
- Usefulness of Harmonic ACE+7 Scalpel in Breast Reconstruction with Extended Latissimus Dorsi Flap: An Open-label Single Institution Pilot Study.Plastic and reconstructive surgery. Global open · 2023Article
- A Prospective Randomised Controlled Study Comparing Ultrasonic Dissector with Electrocautery for Axillary Dissection in Patients of Carcinoma Breast.The Malaysian journal of medical sciences : MJMS · 2021Article
- Definition and severity grading of postoperative lymphatic leakage following inguinal lymph node dissection.Langenbeck's archives of surgery · 2020Article
- Ultrasonic dissection versus electrocautery for immediate prosthetic breast reconstruction.Archives of plastic surgery · 2020Article
- Preventive Effect on Seroma of Use of PEAK PlasmaBlade after Latissimus Dorsi Breast Reconstruction.Plastic and reconstructive surgery. Global open · 2018Article
- [Comparison of postoperative drainage and systemic trauma response after endoscopic and traditional near total thyroidectomy].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Comparison of morbidity-related seroma formation following conventional latissimus dorsi flap versus muscle-sparing latissimus dorsi flap breast reconstruction.Annals of surgical treatment and research · 2017Article
- Effect of Octreotide Injection on Postoperative Drainage After Neck Dissection: A Preliminary Report of a Prospective, Matched Case-Control Study.Clinical and experimental otorhinolaryngology · 2016Article
- Reducing morbidity with surgical adhesives following inguinal lymph node dissections for the treatment of malignant skin tumors.GMS Interdisciplinary plastic and reconstructive surgery DGPW · 2016Article
- Ultrasonic shears versus electrocautery in axillary dissection for breast cancer-a randomized controlled trial.Indian journal of surgical oncology · 2014Article
- Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive-a Laboratory and Clinical Perspective.ISRN surgery · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeroma formation is a frequent complication following radical lymph node dissection (RLND) in patients with metastatic melanoma. Several strategies have been used to prevent fluid accumulation and thereby reduce the duration of postoperative drainage, including fibrin sealants.
methodsThis was a prospective, single-center study in which consecutive patients undergoing surgical treatment of stage III metastatic melanoma by axillary or ilio-inguinal RLND were randomized to receive standard treatment plus fibrinogen/thrombin-coated collagen sealant patch (CSP) or standard treatment alone. The primary endpoint of the study was postoperative duration of drainage.
resultsA total of 70 patients underwent axillary (n = 47) or ilio-inguinal (n = 23) RLND and received CSP plus standard treatment (n = 37) or standard treatment alone (n = 33). Mean duration of drainage was significantly reduced in the CSP group compared with standard treatment (ITT analysis: 20.1 ± 5.1 versus 23.3 ± 5.1 days; p = 0.010). The percentage of patients drainage-free on day 21 was significantly higher in the CSP group compared with the standard treatment group (86% versus 67%; p = 0.049).
conclusionsUse of the tissue sealant resulted in a significant reduction in duration of drainage. Further studies are warranted to confirm these results in different and selected types of lymphadenectomy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.