ReviewEnvironmental health : a global access science source2012
Design and analysis issues in gene and environment studies.
Review in Environmental health : a global access science source, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review.Molecular neurobiology · 2018Pooled it
- The NOD2-Smoking Interaction in Crohn's Disease is likely Specific to the 1007fs Mutation and may be Explained by Age at Diagnosis: A Meta-Analysis and Case-Only Study.EBioMedicine · 2017Pooled it
- Review
- Epigenetics of Autism Spectrum Disorders: A Multi-level Analysis Combining Epi-signature, Age Acceleration, Epigenetic Drift and Rare Epivariations Using Public Datasets.Current neuropharmacology · 2023Article
- Social Determinants of Health Factors for Gene-Environment COVID-19 Research: Challenges and Opportunities.Advanced genetics (Hoboken, N.J.) · 2022Article
- Dissecting schizophrenia phenotypic variation: the contribution of genetic variation, environmental exposures, and gene-environment interactions.Schizophrenia (Heidelberg, Germany) · 2022Article
- Article
- Prediction of Early Childhood Caries Based on Single Nucleotide Polymorphisms Using Neural Networks.Genes · 2021Article
- The Higher Prevalence of Venous Thromboembolism in the Hungarian Roma Population Could Be Due to Elevated Genetic Risk and Stronger Gene-Environmental Interactions.Frontiers in cardiovascular medicine · 2021Article
- Effect of 6p21 region on lung function is modified by smoking: a genome-wide interaction study.Scientific reports · 2020Article
- Neighborhoods to Nucleotides - Advances and gaps for an obesity disparities systems epidemiology model.Current epidemiology reports · 2019Article
- Opportunities for life course research through the integration of data across Clinical and Translational Research Institutes.Journal of clinical and translational science · 2018Article
- Genes Interacting with Occupational Exposures to Low Molecular Weight Agents and Irritants on Adult-Onset Asthma in Three European Studies.Environmental health perspectives · 2017Article
- Exposure Enriched Case-Control (EECC) Design for the Assessment of Gene-Environment Interaction.Genetic epidemiology · 2016Article
- The importance of gene-environment interactions in human obesity.Clinical science (London, England : 1979) · 2016Review
- Susceptibility Factors Relevant for the Association Between Long-Term Air Pollution Exposure and Incident Asthma.Current environmental health reports · 2016Review
- Deciphering Genome Environment Wide Interactions Using Exposed Subjects Only.Genetic epidemiology · 2015Article
- Candidate gene associations with mood disorder, cognitive vulnerability, and fronto-limbic volumes.Brain and behavior · 2014Article
- Gene-environment interactions in cancer epidemiology: a National Cancer Institute Think Tank report.Genetic epidemiology · 2013Article
- Selection of genes for gene-environment interaction studies: a candidate pathway-based strategy using asthma as an example.Environmental health : a global access science source · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Both nurture (environmental) and nature (genetic factors) play an important role in human disease etiology. Traditionally, these effects have been thought of as independent. This perspective is ill informed for non-mendelian complex disorders which result as an interaction between genetics and environment. To understand health and disease we must study how nature and nurture interact. Recent advances in human genomics and high-throughput biotechnology make it possible to study large numbers of genetic markers and gene products simultaneously to explore their interactions with environment. The purpose of this review is to discuss design and analytic issues for gene-environment interaction studies in the "-omics" era, with a focus on environmental and genetic epidemiological studies. We present an expanded environmental genomic disease paradigm. We discuss several study design issues for gene-environmental interaction studies, including confounding and selection bias, measurement of exposures and genotypes. We discuss statistical issues in studying gene-environment interactions in different study designs, such as choices of statistical models, assumptions regarding biological factors, and power and sample size considerations, especially in genome-wide gene-environment studies. Future research directions are also discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.