ArticleNutrition & metabolism2012
A metabolomic investigation of the effects of vitamin E supplementation in humans.
Article in Nutrition & metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- The Role of Vitamin E in Thermal Burn Injuries, Infection, and Sepsis: A Review.Journal of burn care & research : official publication of the American Burn Association · 2022Review
- Vitamin E: Where Are We Now in Vascular Diseases?Life (Basel, Switzerland) · 2022Review
- Untargeted serum metabolites profiling in high-fat diet mice supplemented with enhanced palm tocotrienol-rich fraction using UHPLC-MS.Scientific reports · 2021Article
- The Role of High-Resolution Analytical Techniques in the Development of Functional Foods.International journal of molecular sciences · 2021Review
- Maternal Liver Metabolic Response to Chronic Vitamin D Deficiency Is Determined by Mouse Strain Genetic Background.Current developments in nutrition · 2020Article
- Predictive Modeling for Metabolomics Data.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Metabolomics profiling of xenobiotics in elite athletes: relevance to supplement consumption.Journal of the International Society of Sports Nutrition · 2018Article
- Essential Dietary Bioactive Lipids in Neuroinflammatory Diseases.Antioxidants & redox signaling · 2018Review
- Antioxidants in the Fight Against Atherosclerosis: Is This a Dead End?Current atherosclerosis reports · 2018Review
- α-Tocopherol influences glycaemic control andNutrition & metabolism · 2018Article
- Vitamins, metabolomics, and prostate cancer.World journal of urology · 2017Article
- Serum Metabolomic Response to Long-Term Supplementation withJournal of nutrition and metabolism · 2016Article
- Excessive α-tocopherol exacerbates microglial activation and brain injury caused by acute ischemic stroke.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Human metabolome associates with dietary intake habits among African Americans in the atherosclerosis risk in communities study.American journal of epidemiology · 2014Article
- Postgenomics diagnostics: metabolomics approaches to human blood profiling.Omics : a journal of integrative biology · 2013Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
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backgroundVitamin E is a nutrient with both antioxidant and non-antioxidant activities and has been shown to modulate the function of a number of cell types in vitro and in human studies. However studies have also shown vitamin E to have detrimental interactions and therefore it is important to establish the extent to which this nutrient influences metabolism. Metabolomics can potentially identify nutrient-metabolism interactions and therefore the aim of this study was to use a non-targeted metabolomic approach to identify changes to the plasma metabolome following vitamin E supplementation in humans.
methodsA relatively homogenous healthy adult male population (n = 10) provided a fasting blood sample immediately before and after a 4-week vitamin E supplementation regime (400 mg/d of RRR-α-tocopheryl acetate)) on top of their habitual diet. Plasma samples were analysed for vitamin E and clinical markers. Plasma underwent non-targeted metabolite profiling using liquid chromatography/mass spectroscopy and data was processed using multivariate statistical analysis.
resultsPlasma vitamin E concentrations were significantly increased following supplementation (p < 0.001). A partial least squares-discriminant analysis (PLS-DA) model was able to discriminate between samples taken pre and post vitamin E supplementation (goodness of fit R2Y = 0.82, predictive ability Q2 = 0.50). Variable influence on projection and PLS-DA loadings highlighted a number of discriminating ions that were confirmed as discriminatory through pairwise analysis. From database searches and comparison with standards these metabolites included a number of lysophosphatidylcholine species (16:0, 18:0, 18:1, 18:2, 20:3 and 22:6) that were increased in intensity post supplementation by varying degrees from 4% to 29% with the greatest changes found for lysoPC 22:6 and 20:3.
conclusionsAlthough a small scale study, these results potentially indicate that vitamin E supplementation influences phospholipid metabolism and induces lysoPC generation; a general pro-inflammatory response. Moreover the study identifies novel areas of vitamin E interactions and highlights the potential of metabolomics for elucidating interactions between nutrients and metabolic pathways in nutritional research.
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Registered trials
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