ArticleAnalytical chemistry2013
Multinozzle emitter array chips for small-volume proteomics.
Article in Analytical chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 51 citations in OpenAlex.
- Review of the detection of pathogenic Escherichia coli based-microchip technology.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Review
- Expanding Native Mass Spectrometry to the Masses.Journal of the American Society for Mass Spectrometry · 2024Article
- Moderate Signal Enhancement in Electrospray Ionization Mass Spectrometry by Focusing Electrospray Plume with a Dielectric Layer around the Mass Spectrometer's Orifice.Molecules (Basel, Switzerland) · 2024Article
- Mixed-mode chromatographic performance using nicotinic acid-functionalized chito-oligosaccharide-bonded Ti/Si hybrid monolithic capillary columns.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023Article
- Proteomics Methodologies: The Search of Protein Biomarkers Using Microfluidic Systems Coupled to Mass Spectrometry.Proteomes · 2023Review
- Parallelization with Dual-Trap Single-Column Configuration Maximizes Throughput of Proteomic Analysis.Analytical chemistry · 2022Article
- Interfacing microfluidics with information-rich detection systems for cells, bioparticles, and molecules.Analytical and bioanalytical chemistry · 2022Review
- Application of nanomaterials in proteomics-driven precision medicine.Theranostics · 2022Review
- Microfluidics for core-shell drug carrier particles - a review.RSC advances · 2020Review
- Separation-encoded microparticles for single-cell western blotting.Lab on a chip · 2020Article
- Achieving Stable Electrospray Ionization Mass Spectrometry Detection from Microfluidic Chips.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Quantitation of Intact Proteins in Human Plasma Using Top-Down Parallel Reaction Monitoring-MS.Analytical chemistry · 2018Article
- Direct Analysis of Biofluids by Mass Spectrometry with Microfluidic Voltage-Assisted Liquid Desorption Electrospray Ionization.Analytical chemistry · 2017Article
- A Microstructured Fiber with Defined Borosilicate Regions to Produce a Radial Micronozzle Array for Nanoelectrospray Ionization.Scientific reports · 2016Article
- Biomonitoring of perfluorinated compounds in a drop of blood.Environmental science & technology · 2015Article
- Top-down proteomics of a drop of blood for diabetes monitoring.Journal of proteome research · 2014Article
- Fast quantification of amino acids by microchip electrophoresis-mass spectrometry.Analytical and bioanalytical chemistry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
High-throughput multiplexed proteomics of small-volume biospecimens will generate new opportunities in theranostics. Achieving parallel top-down and bottom-up mass spectrometry analyses of target proteins using a unified apparatus will improve proteome characterization. We have developed a novel silicon-based microfluidic device, multinozzle emitter array chip (MEA chip), as a new platform for small-volume proteomics using liquid chromatography-nanoelectrospray ionization mass spectrometry (LC-nanoESI-MS). We demonstrate parallel, on-chip, and online LC-MS analysis of hemoglobin and its tryptic digests directly from microliters of blood, achieving a detection limit of less than 5 red blood cells. Our MEA chip will enable clinical proteomics of small-volume samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.