ArticleAging and disease2012
The U-shaped Relationship of Traditional Cardiovascular Risk Factors and Adverse Outcomes in Later Life.
Article in Aging and disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Maternal preconception lipid profile and gestational lipid changes in relation to birthweight outcomes.Scientific reports · 2020Trial
- Interrelationship Between Sarcopenia, Frailty and Cardiovascular Disease-The Crucial Role of Obesity in Hypothesis Generation-A Narrative Review.Journal of personalized medicine · 2026Review
- Interrelationships Between Key Cardiovascular Risk Factors, Chronic Kidney Disease and Metabolic Dysfunction-Associated Steatotic Liver Disease.Current cardiology reports · 2026Review
- Anti-aging effects of the adrenal androgens dehydroepiandrosterone and dehydroepiandrosterone sulfate: mechanisms of action and beneficial effects in older people.Endocrine journal · 2026Review
- U-shaped relationship between frailty and non-HDL-cholesterol in the elderly: a cross-sectional study.Frontiers in nutrition · 2025Article
- Living well with diabetes in Alaska.International journal of circumpolar health · 2024Article
- Cardiovascular Risk Factors as Predictors of Nutritional Status in Older Mexican Adults.Nutrients · 2024Article
- The value of earlier-in-life systolic and diastolic blood pressure for cardiovascular risk prediction.iScience · 2024Article
- Ceramides improve cardiovascular risk prediction beyond low-density lipoprotein cholesterol.European heart journal open · 2024Article
- Coronary Event Risk Test (CERT) as a Risk Predictor for the 10-Year Clinical Outcome of Patients with Peripheral Artery Disease.Journal of clinical medicine · 2023Article
- Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England: a retrospective cohort study.European journal of epidemiology · 2023Article
- Metabolic Characteristics of Frail Older People with Diabetes Mellitus-A Systematic Search for Phenotypes.Metabolites · 2023Review
- Article
- Low Values for Blood Pressure, BMI, and Non-HDL Cholesterol and the Risk of Late-Life Dementia.Neurology · 2022Observational
- Prediction of Cardiovascular and All-Cause Mortality After Myocardial Infarction in US Veterans.The American journal of cardiology · 2022Article
- Associations Between Fetal Growth Trajectories and the Development of Myopia by 20 Years of Age.Investigative ophthalmology & visual science · 2020Article
- Low serum albumin, aspartate aminotransferase, and body mass are risk factors for frailty in elderly people with diabetes-a cross-sectional study.BMC geriatrics · 2020Article
- Chronic kidney disease, worsening renal function and outcomes in a heart failure community setting: A UK national study.International journal of cardiology · 2018Article
- Blood pressure and risk of incident Alzheimer's disease dementia by antihypertensive medications and APOE ε4 allele.Annals of neurology · 2018Article
- Low glycated hemoglobin level is associated with severity of frailty in Japanese elderly diabetes patients.Journal of diabetes investigation · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With advancing age traditional cardiovascular risk factors follow a U-shaped relationship with survival outcomes. This relationship has been described as reverse metabolism. The mechanism of such relationship is unclear. However, it appears that malnutrition, inflammation and functional decline are characteristics shared by populations exhibiting the U-shaped risk. Thus, frailty or decline in functional reserve may be the main confounding factor of the relationship between cardiovascular risk factors and adverse outcomes in older patients. Clinical implication of this is not yet clear but more attention should be focused on optimal management of undernutrition and weight loss by improving feeding and maintaining physical activity.
Indexed as
Identifiers
23251851PMC3522512What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.