ArticleScientific reports2012
Digit patterning during limb development as a result of the BMP-receptor interaction.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 77 citations in OpenAlex.
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- Making and shaping endochondral and intramembranous bones.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
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- Retinal defocus and form-deprivation induced regional differential gene expression of bone morphogenetic proteins in chick retinal pigment epithelium.The Journal of comparative neurology · 2020Article
- Of mitogens and morphogens: modelling Sonic Hedgehog mechanisms in vertebrate development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Pattern formation mechanisms of self-organizing reaction-diffusion systems.Developmental biology · 2020Review
- The Developmental Phenotype of the Great Toe in Fibrodysplasia Ossificans Progressiva.Frontiers in cell and developmental biology · 2020Article
- Advanced Chemical Computing Using Discrete Turing Patterns in Arrays of Coupled Cells.Frontiers in chemistry · 2020Article
- Optimization of Bone Scaffold Porosity Distributions.Scientific reports · 2019Article
- Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling.International journal of molecular sciences · 2018Review
- Self-organizing spots get under your skin.PLoS biology · 2017Review
- Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- On the Formation of Digits and Joints during Limb Development.Developmental cell · 2017Article
- Fin-fold development in paddlefish and catshark and implications for the evolution of the autopod.Proceedings. Biological sciences · 2017Article
- Identifying stochastic oscillations in single-cell live imaging time series using Gaussian processes.PLoS computational biology · 2017Article
- An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5'Hoxd-Gli3 antagonism.Nature communications · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Turing models have been proposed to explain the emergence of digits during limb development. However, so far the molecular components that would give rise to Turing patterns are elusive. We have recently shown that a particular type of receptor-ligand interaction can give rise to Schnakenberg-type Turing patterns, which reproduce patterning during lung and kidney branching morphogenesis. Recent knockout experiments have identified Smad4 as a key protein in digit patterning. We show here that the BMP-receptor interaction meets the conditions for a Schnakenberg-type Turing pattern, and that the resulting model reproduces available wildtype and mutant data on the expression patterns of BMP, its receptor, and Fgfs in the apical ectodermal ridge (AER) when solved on a realistic 2D domain that we extracted from limb bud images of E11.5 mouse embryos. We propose that receptor-ligand-based mechanisms serve as a molecular basis for the emergence of Turing patterns in many developing tissues.
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