ArticleScientific reports2012
Interplay between distribution of live cells and growth dynamics of solid tumours.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- The control of acidity in tumor cells: a biophysical model.Scientific reports · 2020Article
- Fine-grained simulations of the microenvironment of vascularized tumours.Scientific reports · 2019Article
- Collective radioresistance of T47D breast carcinoma cells is mediated by a Syncytin-1 homologous protein.PloS one · 2019Article
- Allometric scaling in-vitro.Scientific reports · 2017Article
- Pulsation-limited oxygen diffusion in the tumour microenvironment.Scientific reports · 2017Article
- Echo Chambers: Emotional Contagion and Group Polarization on Facebook.Scientific reports · 2016Article
- BGFit: management and automated fitting of biological growth curves.BMC bioinformatics · 2013Article
- Metabolic scaling in solid tumours.Scientific reports · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experiments show that simple diffusion of nutrients and waste molecules is not sufficient to explain the typical multilayered structure of solid tumours, where an outer rim of proliferating cells surrounds a layer of quiescent but viable cells and a central necrotic region. These experiments challenge models of tumour growth based exclusively on diffusion. Here we propose a model of tumour growth that incorporates the volume dynamics and the distribution of cells within the viable cell rim. The model is suggested by in silico experiments and is validated using in vitro data. The results correlate with in vivo data as well, and the model can be used to support experimental and clinical oncology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.