ArticlePloS one2012
miR-22 controls Irf8 mRNA abundance and murine dendritic cell development.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Modifying immune cells using mouse bone marrow-derived cell exosomes during administration of heat-killed lactic acid bacteriumBiomedical reports · 2025Article
- Current perspective on biological properties of plasmacytoid dendritic cells and dysfunction in gut.Immunity, inflammation and disease · 2023Review
- The Role of microRNAs in Inflammation.International journal of molecular sciences · 2022Review
- MicroRNA-22-3p ameliorates Alzheimer's disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus.Journal of neuroinflammation · 2022Article
- The tissue specific regulation of miR22 expression in the lung and brain by ribosomal protein L29.Scientific reports · 2020Article
- Role of microRNAs in the Regulation of Dendritic Cell Generation and Function.International journal of molecular sciences · 2020Review
- Lower Interferon Regulatory Factor-8 Expression in Peripheral Myeloid Cells Tracks With Adverse Central Nervous System Outcomes in Treated HIV Infection.Frontiers in immunology · 2019Article
- Regulating IRFs in IFN Driven Disease.Frontiers in immunology · 2019Review
- MicroRNA-22 controls interferon alpha production and erythroid maturation in response to infectious stress in mice.Experimental hematology · 2017Article
- Two microRNA signatures for malignancy and immune infiltration predict overall survival in advanced epithelial ovarian cancer.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2017Article
- The development and function of dendritic cell populations and their regulation by miRNAs.Protein & cell · 2017Review
- The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia.PLoS genetics · 2016Article
- Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis.Nature immunology · 2015Article
- The multifaceted biology of plasmacytoid dendritic cells.Nature reviews. Immunology · 2015Review
- MicroRNAs affect dendritic cell function and phenotype.Immunology · 2015Review
- Article
- miR-22 in cardiac remodeling and disease.Trends in cardiovascular medicine · 2014Review
- The role of microRNAs in lymphopoiesis.International journal of hematology · 2014Review
- miRNomes of haematopoietic stem cells and dendritic cells identify miR-30b as a regulator of Notch1.Nature communications · 2013Article
- A microRNA expression atlas of mouse dendritic cell development.Immunology and cell biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
MicroRNAs (miRNAs) have emerged as critical regulators of many cellular responses, through the action of miRNA-induced silencing complex (miRISC)- or miRNA ribonucleoprotein complex (miRNP)-mediated gene repression. Here we studied the role of miRNAs in the development of dendritic cells (DCs), an important immune cell type that is divided into conventional DC (cDC) and plasmacytoid DC (pDC) subsets. We found that miR-22 was highly expressed in mouse CD11c(+) CD11b(+) B220(-) cDCs compared to pDCs, and was induced in DC progenitor cell cultures with GM-CSF, which stimulate CD11c(+) CD11b(+) B220(-) cDC differentiation. Enforced overexpression of miR-22 during DC development enhanced CD11c(+) CD11b(+) B220(-) cDC generation at the expense of pDCs, while miR-22 knockdown demonstrated opposite effects. Moreover, overexpression and knockdown of miR-22 showed significant effects on the mRNA abundance of Irf8, which encodes the transcription factor IRF8 that plays essential roles in DC development. Luciferase reporter assays confirmed that miR-22 binds directly to the 3'UTR of the mouse Irf8 mRNA. Collectively, these results suggest that miR-22 targets Irf8 mRNA for posttranscriptional repression and controls DC subset differentiation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.