ArticlePloS one2012
Ultra-bright and -stable red and near-infrared squaraine fluorophores for in vivo two-photon imaging.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Molecular profiling of the single-cell proteome via gel electrophoresis and 3D single-molecule imaging.Nature communications · 2026Article
- Uniform volumetric single-cell processing for organ-scale molecular phenotyping.Nature biotechnology · 2025Article
- Embracing Complexity: Peptides as Tunable Scaffolds in the Construction of Discrete Supramolecular Systems.Angewandte Chemie (International ed. in English) · 2025Review
- Curved Nanographenes as Stoppers in a [2]Rotaxane with Two-Photon Excited Emission.The Journal of organic chemistry · 2024Article
- Two-Photon Excited Fluorescence Lifetime Imaging of Tetracycline-Labeled Retinal Calcification.Sensors (Basel, Switzerland) · 2023Article
- Single-Particle Tracking ofBiomolecules · 2023Article
- Structural Engineering of Fluorescent Self-Threaded Peptide Probes for Targeted Cell Imaging.Photochemistry and photobiology · 2022Article
- Two-Photon Absorption Activity of BOPHY Derivatives: Insights from Theory.The journal of physical chemistry. A · 2021Article
- Advanced imaging and labelling methods to decipher brain cell organization and function.Nature reviews. Neuroscience · 2021Review
- Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking.Nature communications · 2021Article
- Fluorescent Self-Threaded Peptide Probes for Biological Imaging.Angewandte Chemie (International ed. in English) · 2020Article
- Localized inhibition in theeLife · 2020Article
- Molecular Fluorophores for Deep-Tissue Bioimaging.ACS central science · 2020Review
- Controlling Two-Photon Action Cross Section by Changing a Single Heteroatom Position in Fluorescent Dyes.The journal of physical chemistry letters · 2020Article
- Squaraine Dyes: Molecular Design for Different Applications and Remaining Challenges.Bioconjugate chemistry · 2020Review
- Electronic Nature of Neutral and Charged Two-Photon Absorbing Squaraines for Fluorescence Bioimaging Application.ACS omega · 2019Article
- A Phosphinate-Containing Fluorophore Capable of Selectively Inducing Apoptosis in Cancer Cells.Chembiochem : a European journal of chemical biology · 2019Article
- Inhibitory muscarinic acetylcholine receptors enhance aversive olfactory learning in adulteLife · 2019Article
- Triarylmethane Fluorophores Resistant to Oxidative Photobluing.Journal of the American Chemical Society · 2019Article
- Two-photon probes for in vivo multicolor microscopy of the structure and signals of brain cells.Brain structure & function · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Fluorescent dyes that are bright, stable, small, and biocompatible are needed for high-sensitivity two-photon imaging, but the combination of these traits has been elusive. We identified a class of squaraine derivatives with large two-photon action cross-sections (up to 10,000 GM) at near-infrared wavelengths critical for in vivo imaging. We demonstrate the biocompatibility and stability of a red-emitting squaraine-rotaxane (SeTau-647) by imaging dye-filled neurons in vivo over 5 days, and utility for sensitive subcellular imaging by synthesizing a specific peptide-conjugate label for the synaptic protein PSD-95.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.