ArticlePloS one2012
Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Hair Metabolomic Profiling of Diseased Forest Musk Deer (Animals : an open access journal from MDPI · 2025Article
- The Enrichment of Specific Hair Follicle-Associated Cell Populations in Plucked Hairs Offers an Opportunity to Study Gene Expression Underlying Hair Traits.International journal of molecular sciences · 2022Article
- Age-Related Changes in Hair Shaft Protein Profiling and Genetically Variant Peptides.Forensic science international. Genetics · 2020Article
- Corneocyte proteomics: Applications to skin biology and dermatology.Experimental dermatology · 2018Review
- Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains.Analytical chemistry · 2018Article
- Comparative iTRAQ proteomics revealed proteins associated with horn development in yak.Proteome science · 2018Article
- Proteomic profiling of Pachyonychia congenita plantar callus.Journal of proteomics · 2017Article
- Proteomic analysis of hair shafts from monozygotic twins: Expression profiles and genetically variant peptides.Proteomics · 2017Article
- Alopecia areata.Nature reviews. Disease primers · 2017Review
- Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Article
- A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.The Journal of cell biology · 2015Article
- Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function.Cell death & disease · 2015Article
- Crisp1 and alopecia areata in C3H/HeJ mice.Experimental and molecular pathology · 2014Article
- Human hair shaft proteomic profiling: individual differences, site specificity and cuticle analysis.PeerJ · 2014Article
- Alopecia areata: updates from the mouse perspective.The journal of investigative dermatology. Symposium proceedings · 2013Review
- Proteomic analysis of human keratinocyte response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure.Journal of proteome research · 2013Article
- Distinguishing ichthyoses by protein profiling.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Mutant laboratory mice with distinctive hair phenotypes are useful for identifying genes responsible for hair diseases. The work presented here demonstrates that shotgun proteomic profiling can distinguish hair shafts from different inbred mouse strains. For this purpose, analyzing the total hair shaft provided better discrimination than analyzing the isolated solubilized and particulate (cross-linked) fractions. Over 100 proteins exhibited significant differences among the 11 strains and 5 mutant stocks across the wide spectrum of strains surveyed. Effects on the profile of single gene mutations causing hair shaft defects were profound. Since the hair shaft provides a discrete sampling of the species proteome, with constituents serving important functions in epidermal appendages and throughout the body, this work provides a foundation for non-invasive diagnosis of genetic diseases of hair and perhaps other tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.