ArticlePloS one2012
Pathway and molecular mechanisms for malachite green biodegradation in Exiguobacterium sp. MG2.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 66 citations in OpenAlex.
- Article
- Residual-hybrid dynamic response-surface/machine-learning framework for predicting malachite green removal and biodegradation by a bacterial consortium.Journal of biological engineering · 2026Article
- Impact of Organophosphates on Diversity and Functional Characteristics of Phyllosphere Bacterial Communities ofIndian journal of microbiology · 2025Article
- Biodegradation of malachite green by Pleurotus eryngii: a study on decolorization, mechanism, toxicity, and enzyme.Environmental science and pollution research international · 2024Article
- Catalase-peroxidase StKatG2 fromFrontiers in microbiology · 2024Article
- Efficient malachite green biodegradation by Pseudomonas plecoglossicide MG2: process optimization, application in bioreactors, and degradation pathway.Microbial cell factories · 2023Article
- Microbial Degradation, Spectral analysis and Toxicological Assessment of Malachite Green Dye byMolecules (Basel, Switzerland) · 2022Article
- Microbe mediated remediation of dyes, explosive waste and polyaromatic hydrocarbons, pesticides and pharmaceuticals.Current research in microbial sciences · 2022Review
- Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study.Molecular medicine (Cambridge, Mass.) · 2018Article
- Comparative analyses and structural insights of the novel cytochrome P450 fusion protein family CYP5619 in Oomycetes.Scientific reports · 2018Article
- Metagenomics-Based Discovery of Malachite Green-Degradation Gene Families and Enzymes From Mangrove Sediment.Frontiers in microbiology · 2018Article
- The ability of brown-rot fungus Daedalea dickinsii to decolorize and transform methylene blue dye.World journal of microbiology & biotechnology · 2017Article
- The Comparative Study on the Rapid Decolorization of Azo, Anthraquinone and Triphenylmethane Dyes by Anaerobic Sludge.International journal of environmental research and public health · 2016Article
- Laccase-catalyzed decolorization of malachite green: performance optimization and degradation mechanism.PloS one · 2015Article
- Dye Decolourisation Using TwoWater, air, and soil pollutionArticle
- Decolourisation of Different Dyes by twoWater, air, and soil pollutionArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malachite green (MG), N-methylated diaminotriphenylmethane, is one of the most common dyes in textile industry and has also been used as an effective antifungal agent. However, due to its negative impact on the environment and carcinogenic effects to mammalian cells, there is a significant interest in developing microbial agents to degrade this type of recalcitrant molecules. Here, an Exiguobacterium sp. MG2 was isolated from a river in Yunnan Province of China as one of the best malachite green degraders. This strain had a high decolorization capability even at the concentration of 2500 mg/l and maintained its stable activity within the pH range from 5.0 to 9.0. High-pressure liquid chromatography, liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry were employed to detect the catabolic pathway of MG. Six intermediate products were identified and a potential biodegradation pathway was proposed. This pathway involves a series of reactions of N-demethylation, reduction, benzene ring-removal, and oxidation, which eventually converted N-methylated diaminotriphenylmethane into N, N-dimethylaniline that is the key precursor to MG. Furthermore, our molecular biology experiments suggested that both triphenylmethane reductase gene tmr and cytochrome P450 participated in MG degradation, consistent with their roles in the proposed pathway. Collectively, our investigation is the first report on a biodegradation pathway of triphenylmethane dye MG in bacteria.
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