ArticlePloS one2012
Microbubble mediated thrombus dissolution with diagnostic ultrasound for the treatment of chronic venous thrombi.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Novel Phase Shift Microbubbles, MVT-101, Enhance Sonothrombolysis in a Porcine Model of Deep Vein Thrombosis.Nanotheranostics · 2025Article
- Sonothrombolysis: State-of-the-Art and Potential Applications in Children.Children (Basel, Switzerland) · 2023Review
- Viability of transverse rectus abdominis musculocutaneous flap treated with photobiomodulation and therapeutic ultrasound: an experimental model.Lasers in medical science · 2022Article
- An Analysis of Sonothrombolysis and Cavitation for Retracted and Unretracted Clots Using Microbubbles Versus Low-Boiling-Point Nanodroplets.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Contrast-enhanced ultrasound in pediatric echocardiography.Pediatric radiology · 2021Review
- A thrombolytic therapy using diagnostic ultrasound combined with RGDS-targeted microbubbles and urokinase in a rabbit model.Scientific reports · 2020Article
- Combined ultrasound and photoacoustic imaging of blood clot during microbubble-assisted sonothrombolysis.Journal of biomedical optics · 2019Article
- Successful Recanalization of Thrombotic Occlusion in Pulmonary Artery Stent Using Sonothrombolysis.CASE (Philadelphia, Pa.) · 2019Article
- Cardiomyocyte-targeted and 17β-estradiol-loaded acoustic nanoprobes as a theranostic platform for cardiac hypertrophy.Journal of nanobiotechnology · 2018Article
- In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model.Bioactive materials · 2018Article
- ULTRASOUND INDUCED MICROBUBBLE CAVITATION FOR THE TREATMENT OF CATHETERIZATION INDUCED VASOSPASM.JACC. Basic to translational science · 2017Article
- Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis.Scientific reports · 2017Article
- Treatment of microvascular micro-embolization using microbubbles and long-tone-burst ultrasound: an in vivo study.Ultrasound in medicine & biology · 2015Article
- Prevention of arteriovenous shunt occlusion using microbubble and ultrasound mediated thromboprophylaxis.Journal of the American Heart Association · 2014Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCentral venous catheter (CVC) thrombi result in significant morbidity in children, and currently available treatments are associated with significant risk. We sought to investigate the therapeutic efficacy of microbubble (MB) enhanced sonothrombolysis for aged CVC associated thrombi in vivo. METHODS AND
resultsA model of chronic indwelling CVC in the low superior vena cava with thrombus in situ was established after feasibility and safety testing in 7 pigs; and subsequently applied for repeated, sonothrombolytic treatments in 9 pigs (total 24 treatments). Baseline intracardiac echocardiography (ICE, 10.5F, Siemens), fluoroscopy and saline flushing confirmed the absence of any pre-existing CVC thrombus. A thrombus was then allowed to form and age over 24 hours. The created thrombus was localized and measured by ICE, and transthoracic image guided high mechanical index (MI) two-dimensional US treatments (1.1-1.7 MI; iE33, Philips) applied intermittently whenever intravenously infused MBs (3% MRX-801; NuVox) were visualized near the thrombus (n = 10; Group A). Control pigs (n = 10; Group B) received US without MB. All treatments were randomized. Post-treatment thrombus area by ICE planimetry was compared with pre-treatment measurements. Thrombus area measurements before and after treatment were 0.22 and 0.10 cm(2) respectively in Group A; compared to 0.24 and 0.21 cm(2) in Group B (p = 0.0003). Effectiveness of longer duration US and MB thrombolytic treatments were studied (n = 4), which suggested that near complete thrombus dissolution is possible. No pulmonary emboli, alterations in oxygen saturation, or hemodynamics occurred with either treatment.
conclusionsGuided high MI diagnostic US+systemic MB facilitates reduction of aged CVC associated thrombi in vivo. MB enhanced sonothrombolytic therapy may be a non-invasive safe alternative to thrombolytic agents in treating thrombotic CVC occlusions.
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Registered trials
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