ArticlePloS one2012
Low grade gliomas in eloquent locations - implications for surgical strategy, survival and long term quality of life.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Preoperative assessment of eloquence in neurosurgery: a systematic review.Journal of neuro-oncology · 2023Pooled it
- Health-related quality of life in adults with low-grade gliomas: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Pooled it
- Quality-adjusted life years in glioma patients: a systematic review on currently available data and the lack of evidence-based utilities.Journal of neuro-oncology · 2019Pooled it
- Prevalence of symptoms in glioma patients throughout the disease trajectory: a systematic review.Journal of neuro-oncology · 2018Pooled it
- Continuous dynamic subcortical mapping of corticospinal tract: A systematic review and meta-analysis.Surgical neurology international · 2026Review
- Patient selection and outcome in low-grade glioma surgery.Frontiers in oncology · 2025Article
- Unravelling differences and hallmarks in suspected diffuse low-grade gliomas: a multicentre database study.Brain communications · 2025Article
- Anatomical and subcortical invasiveness in diffuse low-grade astrocytomas differ between IDH status and provide prognostic information.Upsala journal of medical sciences · 2024Article
- Risk of early failure of VP shunts implanted for hydrocephalus after craniotomies for brain tumors in adults.Neurosurgical review · 2022Article
- Eloquent Lower Grade Gliomas, a Highly Vulnerable Cohort: Assessment of Patients' Functional Outcome After Surgery Based on the LoG-Glio Registry.Frontiers in oncology · 2022Article
- Alternative language paradigms for functional magnetic resonance imaging as presurgical tools for inducing crossed cerebro-cerebellar language activations in brain tumor patients.European radiology · 2022Article
- Lower-Grade Gliomas: An Epidemiological Voxel-Based Analysis of Location and Proximity to Eloquent Regions.Frontiers in oncology · 2021Article
- Is it all a matter of size? Impact of maximization of surgical resection in cerebral tumors.Neurosurgical review · 2019Review
- Article
- Imaging practice in low-grade gliomas among European specialized centers and proposal for a minimum core of imaging.Journal of neuro-oncology · 2018Article
- Fatigue in patients with low grade glioma: systematic evaluation of assessment and prevalence.Journal of neuro-oncology · 2017Review
- Network Plasticity and Intraoperative Mapping for Personalized Multimodal Management of Diffuse Low-Grade Gliomas.Frontiers in surgery · 2017Review
- The Value of Pre- and Intraoperative Adjuncts on the Extent of Resection of Hemispheric Low-Grade Gliomas: A Retrospective Analysis.Journal of neurological surgery. Part A, Central European neurosurgery · 2016Article
- Navigated transcranial magnetic stimulation improves the treatment outcome in patients with brain tumors in motor eloquent locations.Neuro-oncology · 2014Article
- Supratentorial gliomas in eloquent areas: which parameters can predict functional outcome and extent of resection?PloS one · 2013Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgical management of suspected LGG remains controversial. A key factor when deciding a surgical strategy is often the tumors' perceived relationship to eloquent brain regions
objectiveTo study the association between tumor location, survival and long-term health related quality of life (HRQL) in patients with supratentorial low-grade gliomas (LGG).
methodsAdults (≥18 years) operated due to newly diagnosed LGG from 1998 through 2009 included from two Norwegian university hospitals. After review of initial histopathology, 153 adults with supratentorial WHO grade II LGG were included in the study. Tumors' anatomical location and the relationship to eloquent regions were graded. Survival analysis was adjusted for known prognostic factors and the initial surgical procedure (biopsy or resection). In long-term survivors, HRQL was assessed with disease specific questionnaires (EORTC QLQ-C30 and BN20) as well as a generic questionnaire (EuroQol 5D).
resultsThere was a significant association between eloquence and survival (log-rank, p<0.001). The estimated 5-year survival was 77% in non-eloquent tumors, 71% in intermediate located tumors and 54% in eloquent tumors. In the adjusted analysis the hazard ratio of increasing eloquence was 1.5 (95% CI 1.1-2.0, p = 0.022). There were no differences in HRQL between patients with eloquent and non-eloquent tumors. The most frequent self-reported symptoms were related to fatigue, cognition, and future uncertainty.
conclusionEloquently located LGGs are associated with impaired survival compared to non-eloquently located LGG, but in long-term survivors HRQL is similar. Although causal inference from observational data should be done with caution, the findings illuminate the delicate balance in surgical decision making in LGGs, and add support to the probable survival benefits of aggressive surgical strategies, perhaps also in eloquent locations.
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