ArticlePloS one2012
Paediatric acute kidney injury in a tertiary hospital in Nigeria: prevalence, causes and mortality rate.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Incidence of acute kidney injury and associated mortality in Nigeria: systematic review and meta-analysis.BMC nephrology · 2026Pooled it
- Kidney disease among children in sub-Saharan Africa: systematic review.Pediatric research · 2015Pooled it
- Trial
- Identifying prognostic factors of severe metabolic acidosis and uraemia in African children with severe falciparum malaria: a secondary analysis of a randomized trial.Malaria journal · 2021Trial
- Incidence and recognition of acute kidney injury in a semirural pediatric ward in Cameroon: a single-center prospective study.BMC nephrology · 2026Observational
- Pediatric Dialysis: From Acute Kidney Injury to Chronic Renal Replacement Therapies: Challenges and Perspectives in Resource-Limited Countries.Diseases (Basel, Switzerland) · 2026Review
- Burden of Paediatric Kidney Diseases in a Tertiary Care Hospital in Harare, Zimbabwe.Clinical medicine insights. Pediatrics · 2023Article
- Burden and severity of deranged electrolytes and kidney function in children seen in a tertiary hospital in Kano, northern Nigeria.PloS one · 2023Article
- Article
- Improvised, emergency peritoneal dialysis in children with acute kidney injury amid war in Tigray, Northern Ethiopia: two teaching cases.Journal of nephrology · 2022Article
- Multiple Organ Dysfunction Syndrome and Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Cerebral Malaria.The American journal of tropical medicine and hygiene · 2022Article
- The Causes of Acute Kidney Injury in Critically Ill Children Who Needs Renal Replacement Therapy.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2022Article
- Etiology, Clinical Profile, and Short-Term Outcome of Children With Acute Kidney Injury.Cureus · 2022Article
- Histomorphological assessment of non-neoplastic renal diseases at autopsy: an institutional experience in Southwestern Nigeria.Malawi medical journal : the journal of Medical Association of Malawi · 2021Article
- Evaluating kidney function using a point-of-care creatinine test in Ugandan children with severe malaria: a prospective cohort study.BMC nephrology · 2021Article
- Management of idiopathic childhood nephrotic syndrome in sub-Saharan Africa: Ibadan consensus statement.Kidney international · 2021Article
- Malaria-Associated Acute Kidney Injury in African Children: Prevalence, Pathophysiology, Impact, and Management Challenges.International journal of nephrology and renovascular disease · 2021Review
- Malaria and acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2020Article
- Acute kidney injury among critically ill neonates in a tertiary hospital in Tanzania; Prevalence, risk factors and outcome.PloS one · 2020Article
- Challenges of Diagnosing Pediatric Posterior Reversible Encephalopathy Syndrome in Resource Poor Settings: A Narrative Review.Global pediatric health · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe modest decline in child mortality in Africa raises the question whether the pattern of diseases associated with acute kidney injury (AKI) in children in Nigeria has changed.
methodsA database of children, aged between one month and 16 years, with AKI (using modified pediatric RIFLE criteria) was reviewed. The cause of AKI was defined as the major underlying disease. The clinical and laboratory features of children with AKI who survived were compared to those who died.
resultsOf the 4 015 children admitted into Lagos University Teaching Hospital between July 2010 and July 2012, 70 episodes of AKI were recorded equalling 17.4 cases per 1000 children. The median age of the children with AKI was 4.8 (range 0.1-14.4) years and 68.6% were males. Acute kidney injury was present in 58 (82.9%) children at admission with 70% in 'failure' category. Primary kidney disease (38.6%), sepsis (25.7%) and malaria (11.4%) were the commonest causes. The primary kidney diseases were acute glomerulonephritis (11) and nephrotic syndrome (8). Nineteen (28.4%) children with AKI died. Need for dialysis [odds ratio: 10.04 (2.94-34.33)], white cell >15 000/mm(3) [odds ratio: 5.72 (1.65-19.89)] and platelet <100 000/mm(3) [odds ratio: 9.56 (2.63-34.77)] were associated with death.
conclusionAcute kidney injury is common in children admitted to hospitals. The common causes remain primary kidney diseases, sepsis and malaria but the contribution of sepsis is rising while malaria and gastroenteritis are declining. Acute kidney injury-related mortality remains high.
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Registered trials
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