ArticlePloS one2012
A unified anatomy ontology of the vertebrate skeletal system.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- An ontological morphological phylogenetic framework for living and extinct ray-finned fishes (Actinopterygii).Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Assessing Bayesian Phylogenetic Information Content of Morphological Data Using Knowledge From Anatomy Ontologies.Systematic biology · 2022Article
- A Logical Model of Homology for Comparative Biology.Systematic biology · 2020Article
- Atypical nested 22q11.2 duplications between LCR22B and LCR22D are associated with neurodevelopmental phenotypes including autism spectrum disorder with incomplete penetrance.Molecular genetics & genomic medicine · 2019Article
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- The Cell Ontology 2016: enhanced content, modularization, and ontology interoperability.Journal of biomedical semantics · 2016Article
- Data Sources for Trait Databases: Comparing the Phenomic Content of Monographs and Evolutionary Matrices.PloS one · 2016Article
- Muscle Logic: New Knowledge Resource for Anatomy Enables Comprehensive Searches of the Literature on the Feeding Muscles of Mammals.PloS one · 2016Article
- Extending gene ontology in the context of extracellular RNA and vesicle communication.Journal of biomedical semantics · 2016Article
- Toward Synthesizing Our Knowledge of Morphology: Using Ontologies and Machine Reasoning to Extract Presence/Absence Evolutionary Phenotypes across Studies.Systematic biology · 2015Article
- Finite element modelling predicts changes in joint shape and cell behaviour due to loss of muscle strain in jaw development.Journal of biomechanics · 2015Article
- Describing the breakbone fever: IDODEN, an ontology for dengue fever.PLoS neglected tropical diseases · 2015Article
- Molecular footprinting of skeletal tissues in the catshark Scyliorhinus canicula and the clawed frog Xenopus tropicalis identifies conserved and derived features of vertebrate calcification.Frontiers in genetics · 2015Article
- Article
- Moving the mountain: analysis of the effort required to transform comparative anatomy into computable anatomy.Database : the journal of biological databases and curation · 2015Article
- The gene expression database for mouse development (GXD): putting developmental expression information at your fingertips.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Review
- The zebrafish anatomy and stage ontologies: representing the anatomy and development of Danio rerio.Journal of biomedical semantics · 2014Article
- Nose to tail, roots to shoots: spatial descriptors for phenotypic diversity in the Biological Spatial Ontology.Journal of biomedical semantics · 2014Article
- Unification of multi-species vertebrate anatomy ontologies for comparative biology in Uberon.Journal of biomedical semantics · 2014Article
- The ontology of craniofacial development and malformation for translational craniofacial research.American journal of medical genetics. Part C, Seminars in medical genetics · 2013Review
Corrections and comments
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Authors and funding
15 authors.
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Abstract
The skeleton is of fundamental importance in research in comparative vertebrate morphology, paleontology, biomechanics, developmental biology, and systematics. Motivated by research questions that require computational access to and comparative reasoning across the diverse skeletal phenotypes of vertebrates, we developed a module of anatomical concepts for the skeletal system, the Vertebrate Skeletal Anatomy Ontology (VSAO), to accommodate and unify the existing skeletal terminologies for the species-specific (mouse, the frog Xenopus, zebrafish) and multispecies (teleost, amphibian) vertebrate anatomy ontologies. Previous differences between these terminologies prevented even simple queries across databases pertaining to vertebrate morphology. This module of upper-level and specific skeletal terms currently includes 223 defined terms and 179 synonyms that integrate skeletal cells, tissues, biological processes, organs (skeletal elements such as bones and cartilages), and subdivisions of the skeletal system. The VSAO is designed to integrate with other ontologies, including the Common Anatomy Reference Ontology (CARO), Gene Ontology (GO), Uberon, and Cell Ontology (CL), and it is freely available to the community to be updated with additional terms required for research. Its structure accommodates anatomical variation among vertebrate species in development, structure, and composition. Annotation of diverse vertebrate phenotypes with this ontology will enable novel inquiries across the full spectrum of phenotypic diversity.
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