Evidence map›Paper›PMID 23251404›Full record

ArticlePloS one2012

Active cognitive lifestyle is associated with positive cognitive health transitions and compression of morbidity from age sixty-five.

Riccardo E Marioni, Michael J Valenzuela, Ardo van den Hout, Carol Brayne, Fiona E Matthews, MRC Cognitive Function and Ageing Study

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 7 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 7 syntheses or guidelines pooled it, 110 citations in OpenAlex.

  1. Digital Cognitive Rehabilitation Platforms for Older Adults in Portugal: A Systematic Review.International journal of environmental research and public health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Riccardo E MarioniDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. riccardo.marioni@ed.ac.uk
Michael J Valenzuela
Ardo van den Hout
Carol Brayne
Fiona E Matthews
MRC Cognitive Function and Ageing Study
University of Cambridge · GBMedical Research Council · GBUniversity College London · GBUniversity of Sydney · AU

Funding

Medical Research Council G9901400Medical Research Council MRC G9901400Medical Research Council UC_US_A030_0031
6 · The paper itself

Abstract

backgroundThree factors commonly used as measures of cognitive lifestyle are education, occupation, and social engagement. This study determined the relative importance of each variable to long term cognitive health in those with and without severe cognitive impairment.

methodsData came from 12,470 participants from a multi-centre population-based cohort (Medical Research Council Cognitive Function and Ageing Study). Respondents were aged 65 years and over and were followed-up over 16 years. Cognitive states of no impairment, slight impairment, and moderate/severe impairment were defined, based on scores from the Mini-Mental State Examination. Multi-state modelling was used to investigate links between component cognitive lifestyle variables, cognitive state transitions over time, and death.

resultsHigher educational attainment and a more complex mid-life occupation were associated with a lower risk of moving from a non-impaired to a slightly impaired state (hazard ratios 0.5 and 0.8), but with increased mortality from a severely impaired state (1.3 and 1.1). More socially engaged individuals had a decreased risk of moving from a slightly impaired state to a moderately/severely impaired state (0.7). All three cognitive lifestyle variables were linked to an increased chance of cognitive recovery back to the non-impaired state.

conclusionsIn those without severe cognitive impairment, different aspects of cognitive lifestyle predict positive cognitive transitions over time, and in those with severe cognitive impairment, a reduced life-expectancy. An active cognitive lifestyle is therefore linked to compression of cognitive morbidity in late life.

Indexed as

Health TransitionLife StyleAgedAged, 80 and overCognitionCognition DisordersCohort StudiesEducational StatusFemaleFollow-Up StudiesHumansLife ExpectancyMaleOccupations

Identifiers

PMID23251404
PMCPMC3521012
OpenAlexW2088682194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.