ArticlePloS one2012
Uniparental markers of contemporary Italian population reveals details on its pre-Roman heritage.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Western Hunter-Gatherer genetic ancestry contributes to human longevity in the Italian population.GeroScience · 2026Article
- Ancient DNA and spatial modeling reveal a pre-Inca trans-Andean parrot trade.Nature communications · 2026Article
- Uniparental analysis of Deep Maniot Greeks reveals genetic continuity from the pre-Medieval era.Communications biology · 2026Article
- Rare uniparental lineages reveal external ancestries in the gene pool of the Italian linguistic enclave of Grecìa Salentina.Scientific reports · 2025Article
- The genomic portrait of the Picene culture provides new insights into the Italic Iron Age and the legacy of the Roman Empire in Central Italy.Genome biology · 2024Article
- Helena's Many Daughters: More Mitogenome Diversity behind the Most Common West Eurasian mtDNA Control Region Haplotype in an Extended Italian Population Sample.International journal of molecular sciences · 2022Article
- Article
- Genetic history of Calabrian Greeks reveals ancient events and long term isolation in the Aspromonte area of Southern Italy.Scientific reports · 2021Article
- The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remains.Scientific reports · 2020Article
- Genomic history of the Italian population recapitulates key evolutionary dynamics of both Continental and Southern Europeans.BMC biology · 2020Article
- Article
- A finely resolved phylogeny of Y chromosome Hg J illuminates the processes of Phoenician and Greek colonizations in the Mediterranean.Scientific reports · 2018Article
- Whole Y-chromosome sequences reveal an extremely recent origin of the most common North African paternal lineage E-M183 (M81).Scientific reports · 2017Article
- The distribution of mitochondrial DNA haplogroup H in southern Iberia indicates ancient human genetic exchanges along the western edge of the Mediterranean.BMC genetics · 2017Article
- Ancient and recent admixture layers in Sicily and Southern Italy trace multiple migration routes along the Mediterranean.Scientific reports · 2017Article
- Y-chromosomal analysis of Greek Cypriots reveals a primarily common pre-Ottoman paternal ancestry with Turkish Cypriots.PloS one · 2017Article
- Complex interplay between neutral and adaptive evolution shaped differential genomic background and disease susceptibility along the Italian peninsula.Scientific reports · 2016Article
- The Italian genome reflects the history of Europe and the Mediterranean basin.European journal of human genetics : EJHG · 2016Article
- The Greeks in the West: genetic signatures of the Hellenic colonisation in southern Italy and Sicily.European journal of human genetics : EJHG · 2016Article
- Mitogenomes from The 1000 Genome Project reveal new Near Eastern features in present-day Tuscans.PloS one · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccording to archaeological records and historical documentation, Italy has been a melting point for populations of different geographical and ethnic matrices. Although Italy has been a favorite subject for numerous population genetic studies, genetic patterns have never been analyzed comprehensively, including uniparental and autosomal markers throughout the country. METHODS/PRINCIPAL
findingsA total of 583 individuals were sampled from across the Italian Peninsula, from ten distant (if homogeneous by language) ethnic communities--and from two linguistic isolates (Ladins, Grecani Salentini). All samples were first typed for the mitochondrial DNA (mtDNA) control region and selected coding region SNPs (mtSNPs). This data was pooled for analysis with 3,778 mtDNA control-region profiles collected from the literature. Secondly, a set of Y-chromosome SNPs and STRs were also analyzed in 479 individuals together with a panel of autosomal ancestry informative markers (AIMs) from 441 samples. The resulting genetic record reveals clines of genetic frequencies laid according to the latitude slant along continental Italy--probably generated by demographical events dating back to the Neolithic. The Ladins showed distinctive, if more recent structure. The Neolithic contribution was estimated for the Y-chromosome as 14.5% and for mtDNA as 10.5%. Y-chromosome data showed larger differentiation between North, Center and South than mtDNA. AIMs detected a minor sub-Saharan component; this is however higher than for other European non-Mediterranean populations. The same signal of sub-Saharan heritage was also evident in uniparental markers. CONCLUSIONS/SIGNIFICANCE: Italy shows patterns of molecular variation mirroring other European countries, although some heterogeneity exists based on different analysis and molecular markers. From North to South, Italy shows clinal patterns that were most likely modulated during Neolithic times.
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