ArticlePsychiatry investigation2012
Prominent clinical dimension, duration of illness and treatment response in schizophrenia: a naturalistic study.
Article in Psychiatry investigation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Early-Age onset of psychotic spectrum symptoms is highly prevalent and associated with greater illness severity in schizophrenia spectrum disorders that develop later in life.Social psychiatry and psychiatric epidemiology · 2026Observational
- Gender differences in clinical and biochemical parameters among patients hospitalized for schizophrenia: towards precision medicine.European archives of psychiatry and clinical neuroscience · 2024Article
- Comparison between olanzapine and aripiprazole treatment for 104 weeks after hospital discharge in schizophrenia spectrum disorders: a multicenter retrospective cohort study in a real-world setting.Psychopharmacology · 2023Article
- High Rate of Discontinuation during Long-Acting Injectable Antipsychotic Treatment in Patients with Psychotic Disorders.Biomedicines · 2023Article
- Serum Progesterone and Testosterone Levels in Schizophrenia Patients at Different Stages of Treatment.Journal of molecular neuroscience : MN · 2021Article
- Differences in Total Score of Positive and Negative Syndrome Scale between Bataknese and Javanese Men with Schizophrenia Receiving Risperidone Treatment.Open access Macedonian journal of medical sciences · 2019Article
- Age at Onset and Social Cognitive Impairment in Clinically Stabilized Patients with Schizophrenia: An Ecological Cross-Sectional Study.Iranian journal of psychiatry · 2018Article
- Cognitive correlates of neuroimaging abnormalities in the onset of schizophrenia: A case report.World journal of psychiatry · 2017Article
- Impaired prefrontal activity to regulate the intrinsic motivation-action link in schizophrenia.NeuroImage. Clinical · 2017Article
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4 authors.
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Abstract
objectivePreliminary data indicate that predominant positive symptoms are predictive of subsequent treatment response, while negative and cognitive symptoms are associated with poor outcome. Purpose of the present study was to investigate the relation between the predominant clinical dimension, duration of illness and acute antipsychotic response in a sample of schizophrenic inpatients.
methodsFifty-one schizophrenic inpatients, receiving an antipsychotic mono-therapy, were dimensionally assessed at the admission in the Acute Psychiatric Unit of the University of Milan. Treatment response was selected as parameter of outcome and defined as a reduction >50% of baseline total The Positive and Negative Syndrome Scale (PANSS) score. Demographic and clinical variables between responders and non-responders were compared using one-way analysis of variance for continuous variables and χ(2) test for dichotomous ones. Binary logistic regression was performed to find if dimensional scores and duration of illness were associated with acute antipsychotic response.
resultsA longer duration of illness was found in non-responders respect to responders (15.61 years vs. 8.28 years)(F=4.98, p=0.03). Higher scores on PANSS positive sub-scale (OR=1.3, p=0.03), lower scores on cognitive PANSS scores (OR=0.75, p=0.05) and shorter duration of illness (OR=0.93, p=0.04) were found to be predictive of acute antipsychotic response.
conclusionThese preliminary results show that a long duration of illness as well as a more severe cognitive impairment is predictive of treatment non-response, indicating a worse outcome for chronic patients with predominant cognitive symptoms.
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