ArticleProceedings of the National Academy of Sciences of the United States of America2013
Migration of cells in a social context.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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Who cites it
55 citing papers in PubMed.
- Mechanical polarity links adhesion-regulated protrusions to directional stability in glioblastoma cell migration.PLoS computational biology · 2026Article
- Liquid crystal-like self-organization of glioblastoma is associated with consistent migration for high cell densities.Scientific reports · 2026Article
- Physical models of embryonic epithelial healing.PLoS computational biology · 2026Review
- Quantifying Information Exchange Between Cells in Inflammaging.Bioengineering (Basel, Switzerland) · 2026Article
- Contrasting Impacts of Targeted Disruption of the Cancer Stem Cell Marker CD133 and Its Epigenetic Regulator TRIM28 in Colorectal Cancer Cells.International journal of molecular sciences · 2025Article
- Regulation of epithelial cell jamming transition by cytoskeleton and cell-cell interactions.Biophysics reviews · 2024Review
- Induction of in vivo-like ciliation in confluent monolayers of re-differentiated equine oviduct epithelial cells†.Biology of reproduction · 2024Article
- Preclinical Models and Technologies in Glioblastoma Research: Evolution, Current State, and Future Avenues.International journal of molecular sciences · 2023Review
- Implementation of miniaturized modular-array fluorescence microscopy for long-term live-cell imaging.Applied optics · 2023Article
- Quantifying heterogeneity to drug response in cancer-stroma kinetics.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Collective rotational motion of freely expanding T84 epithelial cell colonies.Journal of the Royal Society, Interface · 2023Article
- The Social Norm of Hematopoietic Stem Cells and Dysregulation in Leukemia.International journal of molecular sciences · 2022Review
- Interplay among cell migration, shaping, and traction force on a matrix with cell-scale stiffness heterogeneity.Biophysics and physicobiology · 2022Article
- Density-Dependent Migration Characteristics of Cancer Cells Driven by Pseudopod Interaction.Frontiers in cell and developmental biology · 2022Article
- Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells.Scientific reports · 2021Article
- Learning the dynamics of cell-cell interactions in confined cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Bioimage Analysis and Cell Motility.Patterns (New York, N.Y.) · 2021Review
- Rules of collective migration: from the wildebeest to the neural crest.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Interplay Between the Persistent Random Walk and the Contact Inhibition of Locomotion Leads to Collective Cell Behaviors.Bulletin of mathematical biology · 2019Article
- Automated microfluidic cell culture of stem cell derived dopaminergic neurons.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In multicellular organisms and complex ecosystems, cells migrate in a social context. Whereas this is essential for the basic processes of life, the influence of neighboring cells on the individual remains poorly understood. Previous work on isolated cells has observed a stereotypical migratory behavior characterized by short-time directional persistence with long-time random movement. We discovered a much richer dynamic in the social context, with significant variations in directionality, displacement, and speed, which are all modulated by local cell density. We developed a mathematical model based on the experimentally identified "cellular traffic rules" and basic physics that revealed that these emergent behaviors are caused by the interplay of single-cell properties and intercellular interactions, the latter being dominated by a pseudopod formation bias mediated by secreted chemicals and pseudopod collapse following collisions. The model demonstrates how aspects of complex biology can be explained by simple rules of physics and constitutes a rapid test bed for future studies of collective migration of individual cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.