ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2013
Human papillomavirus DNA is rarely detected in colorectal carcinomas and not associated with microsatellite instability: the Seattle colon cancer family registry.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Human papillomavirus and colorectal cancer.Medical oncology (Northwood, London, England) · 2018Pooled it
- Mendelian randomization analyses support causal relationships between HPV infection and colorectal cancer.Discover oncology · 2024Article
- Dynamic impact of virome on colitis and colorectal cancer: Immunity, inflammation, prevention and treatment.Seminars in cancer biology · 2022Review
- Article
- Human Papillomavirus and Risk of Colorectal Cancer: An Analysis of Nationwide Claims Data.Medicina (Kaunas, Lithuania) · 2022Article
- Viruses in Cancers of the Digestive System: Active Contributors or Idle Bystanders?International journal of molecular sciences · 2020Review
- Human Papillomaviruses and Epstein-Barr Virus Interactions in Colorectal Cancer: A Brief Review.Pathogens (Basel, Switzerland) · 2020Review
- Does human papillomavirus cause human colorectal cancer? Applying Bradford Hill criteria postulates.Ecancermedicalscience · 2020Article
- Article
- Molecular evidence of high-risk human papillomavirus infection in colorectal tumours from Cuban patients.Memorias do Instituto Oswaldo Cruz · 2016Article
- Impact of the immune system and immunotherapy in colorectal cancer.Journal of gastrointestinal oncology · 2015Review
- Human papillomavirus does not have a causal role in colorectal carcinogenesis.World journal of gastroenterology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPersistent infection with oncogenic human papillomavirus (HPV) types-16 and -18 is an established cause of cervical and other cancers. Some studies report detection of oncogenic HPV DNA in colorectal carcinomas, with prevalence estimates as high as 84%. However, other studies report detecting no HPV DNA in colorectal tumors.
methodsTo evaluate the prevalence of HPV in colorectal cancer subsets, we conducted a case-case comparison study. This study included 555 cases of incident colorectal cancer from the Seattle Colon Cancer Family Registry (CCFR), ages 20 to 74 years and diagnosed between 1998 and 2002. Standardized interviews were used to elicit demographics and risk factor data. Tumor DNA was assayed for HPV-16 and -18 DNA using real-time PCR. Microsatellite instability (MSI) status was assessed using a standard 10-marker panel and confirmed with immunohistochemical staining. Prevalence estimates were calculated for the overall sample, and stratified by patient and tumor characteristics. Fisher exact test was used to compare prevalence between strata.
resultsHPV-16 DNA was detected in 2% of colorectal tumors, but no HPV-18 DNA was detected. HPV-16 prevalence did not vary between cases according to sex, age, race, smoking-status, or MSI-status (P > 0.05). HPV-16 prevalence in rectal carcinomas was 5% compared with 1% in colon carcinomas (P = 0.03).
conclusionsAmong a large sample of colorectal carcinomas, prevalence of HPV-16 and -18 was very low. Prior studies detecting high HPV prevalence in colorectal carcinomas are likely the result of contamination from the anal canal or clinical processing. IMPACT: HPV is unlikely to play a large role in colorectal carcinogenesis.
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