ArticleBrain : a journal of neurology2012
Abnormal thalamocortical structural and functional connectivity in juvenile myoclonic epilepsy.
Article in Brain : a journal of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05450822 (The BrainDrugs-Epilepsy Study), which is not on this map. Cited by 84 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy
Who cites it
84 citing papers in PubMed, 171 citations in OpenAlex.
- Motor co-activation in siblings of patients with juvenile myoclonic epilepsy: an imaging endophenotype?Brain : a journal of neurology · 2014Trial
- Auditory gamma-band synchronization and attentional performance in juvenile myoclonic epilepsy.Epilepsia open · 2026Article
- Juvenile myoclonic epilepsy heterogeneity uncovered: Z-mapped imaging endophenotypes of cortical and subcortical structures and their clinical, cognitive and psychiatric features.Brain communications · 2026Article
- Article
- Enhanced response inhibition in patients with drug-resistant juvenile myoclonic epilepsy: Event-related potentials evidence of excitatory-inhibitory imbalance.Epilepsia open · 2025Article
- Increased volumes of the precuneus and the pallidum in idiopathic generalized epilepsy.Scientific reports · 2025Article
- Dissociation of Structural and Functional Connectivity and Metabolism in the Neocortex of Idiopathic Generalized Epilepsy: A Simultaneous PET/MRI Multimodal Study.AJNR. American journal of neuroradiology · 2025Article
- Progressive Myoclonus Epilepsy: Distinctive MRI Changes in Cerebellar and Motor Networks.Annals of clinical and translational neurology · 2025Article
- A generalized epilepsy network derived from brain abnormalities and deep brain stimulation.Nature communications · 2025Article
- Development and Validation of Artificial Intelligence Models for Prognosis Prediction of Juvenile Myoclonic Epilepsy with Clinical and Radiological Features.Journal of clinical medicine · 2024Article
- Decomposed FDG PET-based phenotypic heterogeneity predicting clinical prognosis and decision-making in temporal lobe epilepsy patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Article
- Neurostimulation for Generalized Epilepsy: Should Therapy be Syndrome-specific?Neurosurgery clinics of North America · 2024Review
- Exploring individual fixel-based white matter abnormalities in epilepsy.Brain communications · 2024Article
- Quantitative susceptibility mapping identifies hippocampal and other subcortical grey matter tissue composition changes in temporal lobe epilepsy.Human brain mapping · 2023Article
- Facial Emotion Recognition in Patients with Juvenile Myoclonic Epilepsy.Journal of clinical medicine · 2023Article
- Altered neurovascular coupling in children with idiopathic generalized epilepsy.CNS neuroscience & therapeutics · 2023Article
- The BrainDrugs-epilepsy study: A prospective open-label cohort precision medicine study in epilepsy.Neuroscience applied · 2023Article
- Case Report: Zolpidem's paradoxical restorative action: A case report of functional brain imaging.Frontiers in neuroscience · 2023Article
- Development and Validation of MRI-Based Radiomics Models for Diagnosing Juvenile Myoclonic Epilepsy.Korean journal of radiology · 2022Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Juvenile myoclonic epilepsy is the most common idiopathic generalized epilepsy, characterized by frequent myoclonic jerks, generalized tonic-clonic seizures and, less commonly, absences. Neuropsychological and, less consistently, anatomical studies have indicated frontal lobe dysfunction in the disease. Given its presumed thalamo-cortical basis, we investigated thalamo-cortical structural connectivity, as measured by diffusion tensor imaging, in a cohort of 28 participants with juvenile myoclonic epilepsy and detected changes in an anterior thalamo-cortical bundle compared with healthy control subjects. We then investigated task-modulated functional connectivity from the anterior thalamic region identified using functional magnetic resonance imaging in a task consistently shown to be impaired in this group, phonemic verbal fluency. We demonstrate an alteration in task-modulated connectivity in a region of frontal cortex directly connected to the thalamus via the same anatomical bundle, and overlapping with the supplementary motor area. Further, we show that the degree of abnormal connectivity is related to disease severity in those with active seizures. By integrating methods examining structural and effective interregional connectivity, these results provide convincing evidence for abnormalities in a specific thalamo-cortical circuit, with reduced structural and task-induced functional connectivity, which may underlie the functional abnormalities in this idiopathic epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.