ArticleThe Journal of biological chemistry2013
Non-canonical maturation of two papain-family proteases in Toxoplasma gondii.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
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- A cathepsin C-like protease post-translationally modifiesbioRxiv : the preprint server for biology · 2023Article
- The Toxoplasma plant-like vacuolar compartment (PLVAC).The Journal of eukaryotic microbiology · 2022Review
- The Autophagy Machinery in Human-Parasitic Protists; Diverse Functions for Universally Conserved Proteins.Cells · 2021Review
- Discovery and Optimization of Triazine Nitrile Inhibitors ofACS chemical neuroscience · 2020Article
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- The Toxoplasma Vacuolar HCell reports · 2019Article
- Characterization of metalloproteases and serine proteases of Toxoplasma gondii tachyzoites and their effect on epithelial cells.Parasitology research · 2019Article
- Cysteine proteases in protozoan parasites.PLoS neglected tropical diseases · 2018Review
- Intersection of endocytic and exocytic systems in Toxoplasma gondii.Traffic (Copenhagen, Denmark) · 2018Article
- Article
- The parasiteThe Journal of cell biology · 2017Article
- Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection.Nature microbiology · 2017Article
- Disruptions of Host Immunity and Inflammation by Giardia Duodenalis: Potential Consequences for Co-Infections in the Gastro-Intestinal Tract.Pathogens (Basel, Switzerland) · 2015Review
- Secretion of Polypeptide Crystals from Tetrahymena thermophila Secretory Organelles (Mucocysts) Depends on Processing by a Cysteine Cathepsin, Cth4p.Eukaryotic cell · 2015Article
- Identification and characterization of a cathepsin-L-like peptidase in Eimeria tenella.Parasitology research · 2014Article
- Characterization of the chloroquine resistance transporter homologue in Toxoplasma gondii.Eukaryotic cell · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Proteases regulate key events during infection by the pervasive intracellular parasite Toxoplasma gondii. Understanding how parasite proteases mature from an inactive zymogen to an active enzyme is expected to inform new strategies for blocking their actions. Herein, we show that T. gondii cathepsin B protease (TgCPB) does not undergo self-maturation but instead requires the expression of a second papain-family cathepsin protease, TgCPL. Using recombinant enzymes we also show that TgCPL is capable of partially maturing TgCPB in vitro. Consistent with this interrelationship, antibodies with validated specificity detected TgCPB in the lysosome-like vacuolar compartment along with TgCPL. Our findings also establish that TgCPB does not localize to the rhoptries as previously reported. Accordingly, rhoptry morphology and rhoptry protein maturation are normal in TgCPB knock-out parasites. Finally, we show that although maturation of TgCPL is independent of TgCPB, it may involve an additional protease(s) in conjunction with self-maturation.
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Registered trials
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