ArticlePlant physiology2013
Reciprocal interaction of the circadian clock with the iron homeostasis network in Arabidopsis.
Article in Plant physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 89 citations in OpenAlex.
- Mineral nutrients as regulators of plant flowering time: A molecular perspective.Journal of integrative plant biology · 2026Review
- Magnesium: An overlooked signalling ion in plant physiology and circadian regulation.Quantitative plant biology · 2026Review
- Barriers and carriers for transition metal homeostasis in plants.Plant communications · 2025Review
- Shedding light on iron nutrition: exploring intersections of transcription factor cascades in light and iron deficiency signaling.Journal of experimental botany · 2025Review
- Flexible iron: disorder in the ironome brings order to protein structure and function.Frontiers in molecular biosciences · 2025Article
- The clock-associated LUX ARRHYTHMO regulates high-affinity nitrate transport in Arabidopsis roots.The Plant journal : for cell and molecular biology · 2024Article
- Environmental F actors coordinate circadian clock function and rhythm to regulate plant development.Plant signaling & behavior · 2023Review
- Beyond NPK: Mineral Nutrient-Mediated Modulation in Orchestrating Flowering Time.Plants (Basel, Switzerland) · 2023Review
- The circadian clock ticks in plant stress responses.Stress biology · 2022Review
- The biology of time: dynamic responses of cell types to developmental, circadian and environmental cues.The Plant journal : for cell and molecular biology · 2022Review
- Article
- Single-cell RNA sequencing of batch Chlamydomonas cultures reveals heterogeneity in their diurnal cycle phase.The Plant cell · 2021Article
- Co-expression networks in Chlamydomonas reveal significant rhythmicity in batch cultures and empower gene function discovery.The Plant cell · 2021Article
- Magnesium maintains the length of the circadian period in Arabidopsis.Plant physiology · 2021Article
- Network Topological Analysis for the Identification of Novel Hubs in Plant Nutrition.Frontiers in plant science · 2021Article
- Assessing Global Circadian Rhythm Through Single-Time-Point Transcriptomic Analysis.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Coronatine is more potent than jasmonates in regulating Arabidopsis circadian clock.Scientific reports · 2020Article
- Putative cis-Regulatory Elements Predict Iron Deficiency Responses in Arabidopsis Roots.Plant physiology · 2020Article
- Deconstructing the genetic architecture of iron deficiency chlorosis in soybean using genome-wide approaches.BMC plant biology · 2020Article
- Profile of Mary Lou Guerinot.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In plants, iron (Fe) uptake and homeostasis are critical for survival, and these processes are tightly regulated at the transcriptional and posttranscriptional levels. Circadian clocks are endogenous oscillating mechanisms that allow an organism to anticipate environmental changes to coordinate biological processes both with one another and with the environmental day/night cycle. The plant circadian clock controls many physiological processes through rhythmic expression of transcripts. In this study, we examined the expression of three Fe homeostasis genes (IRON REGULATED TRANSPORTER1 [IRT1], BASIC HELIX LOOP HELIX39, and FERRITIN1) in Arabidopsis (Arabidopsis thaliana) using promoter:LUCIFERASE transgenic lines. Each of these promoters showed circadian regulation of transcription. The circadian clock monitors a number of clock outputs and uses these outputs as inputs to modulate clock function. We show that this is also true for Fe status. Fe deficiency results in a lengthened circadian period. We interrogated mutants impaired in the Fe homeostasis response, including irt1-1, which lacks the major high-affinity Fe transporter, and fit-2, which lacks Fe deficiency-induced TRANSCRIPTION FACTOR1, a basic helix-loop-helix transcription factor necessary for induction of the Fe deficiency response. Both mutants exhibit symptoms of Fe deficiency, including lengthened circadian period. To determine which components are involved in this cross talk between the circadian and Fe homeostasis networks, we tested clock- or Fe homeostasis-related mutants. Mutants defective in specific clock gene components were resistant to the change in period length under different Fe conditions observed in the wild type, suggesting that these mutants are impaired in cross talk between Fe homeostasis and the circadian clock.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.