ArticleCell stress & chaperones2013
Identification, genomic organization, and oxidative stress response of a sigma class glutathione S-transferase gene (AccGSTS1) in the honey bee, Apis cerana cerana.
Article in Cell stress & chaperones, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 77 citations in OpenAlex.
- Structural and Functional Insights into a Honey Bee Omega-Class Glutathione S-Transferase Mediating Chemical Sequestration and Antioxidative Stress.Journal of agricultural and food chemistry · 2026Article
- Oxidative stress-triggered UMPylation of SodA by YdiU modulates oxidative stress resistance in Salmonella.Veterinary research · 2026Article
- Identification and Characterization of the Detoxification Genes from the Transcriptome ofInsects · 2026Article
- Article
- Glutathione S-Transferase (GST) Activities and Gene Expression Patterns of DifferentInternational journal of molecular sciences · 2025Article
- Glutathione S-transferase TcGSTu1 contributes to defense against eucalyptol in Tribolium castaneum.Genetica · 2024Article
- Combined Toxic Effects of Lead and Glyphosate onInsects · 2024Article
- Mechanisms of Pathogen and Pesticide Resistance in Honey Bees.Physiology (Bethesda, Md.) · 2024Review
- Article
- Functional and Structural Diversity of Insect Glutathione S-transferases in Xenobiotic Adaptation.International journal of biological sciences · 2022Review
- The Key Glutathione S-Transferase Family Genes Involved in the Detoxification of Rice Gramine in Brown PlanthopperInsects · 2021Article
- Structural and Functional Characterization of One Unclassified Glutathione S-Transferase in Xenobiotic Adaptation ofInternational journal of molecular sciences · 2021Article
- Cloning and expression studies on glutathione S-transferase like-gene in honey bee for its role in oxidative stress.Cell stress & chaperones · 2021Article
- Detection and functional characterization of sigma class GST in Phlebotomus argentipes and its role in stress tolerance and DDT resistance.Scientific reports · 2019Article
- Identification of an inositol-3-phosphate synthase 1-B gene (AccIPS1-B) from Apis cerana cerana and its role in abiotic stress.Cell stress & chaperones · 2019Article
- Role of AccMGST1 in oxidative stress resistance in Apis cerana cerana.Cell stress & chaperones · 2019Article
- Honey bee colony performance and health are enhanced by apiary proximity to US Conservation Reserve Program (CRP) lands.Scientific reports · 2019Article
- Laboratory bioassays on the response of honey bee (Apis mellifera L.) glutathione S-transferase and acetylcholinesterase to the oral exposure to copper, cadmium, and lead.Environmental science and pollution research international · 2019Article
- The Wisdom of Honeybee Defenses Against Environmental Stresses.Frontiers in microbiology · 2018Review
- Effect of Sublethal Doses of Imidacloprid on the Biological Performance of Aphid EndoparasitoidFrontiers in physiology · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutathione S-transferases (GSTs) are members of a multifunctional antioxidant enzyme superfamily that play pivotal roles in both detoxification and protection against oxidative damage caused by reactive oxygen species. In this study, a complementary DNA (cDNA) encoding a sigma class GST was identified in the Chinese honey bee, Apis cerana cerana (AccGSTS1). AccGSTS1 was constitutively expressed in all tissues of adult worker bees, including the brain, fat body, epidermis, muscle, and midgut, with particularly robust transcription in the fat body. Relative messenger RNA expression levels of AccGSTS1 at different developmental stages varied, with the highest levels of expression observed in adults. The potential function of AccGSTS1 in cellular defenses against abiotic stresses (cold, heat, UV, H2O2, HgCl2, and insecticides) was investigated. AccGSTS1 was significantly upregulated in response to all of the treatment conditions examined, although the induction levels were varied. Recombinant AccGSTS1 protein showed characteristic glutathione-conjugating catalytic activity toward 1-chloro-2,4-dinitrobenzene. Functional assays revealed that AccGSTS1 could remove H2O2, thereby protecting DNA from oxidative damage. Escherichia coli overexpressing AccGSTS1 showed long-term resistance under conditions of oxidative stress. Together, these results suggest that AccGSTS1 is a crucial antioxidant enzyme involved in cellular antioxidant defenses and honey bee survival.
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