ArticleLab on a chip2013
Adhesive micro-line periodicity determines guidance of axonal outgrowth.
Article in Lab on a chip, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Feedback-controlled dynamics of neuronal cells on directional surfaces.Biophysical journal · 2022Article
- Neuronal Growth and Formation of Neuron Networks on Directional Surfaces.Biomimetics (Basel, Switzerland) · 2021Article
- Multi-curvature micropatterns unveil distinct calcium and mitochondrial dynamics in neuronal networks.Lab on a chip · 2021Article
- Article
- Fabrication of Tapered 3D Microstructure Arrays Using Dual-Exposure Lithography (DEL).Micromachines · 2020Article
- Variations of Elastic Modulus and Cell Volume with Temperature for Cortical Neurons.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Article
- Functional imaging of neuron-astrocyte interactions in a compartmentalized microfluidic device.Microsystems & nanoengineering · 2016Article
- Cell-Type Dependent Effect of Surface-Patterned Microdot Arrays on Neuronal Growth.Frontiers in neuroscience · 2016Article
- Article
- Effects of surface asymmetry on neuronal growth.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Adhesive micro-lines of various sub-cellular geometries were created using a non-traditional micro stamping technique. This technique employed the use of commercially available diffraction gratings as the molds for the micro stamps, a method which is quick and inexpensive, and which could easily be adopted as a patterning tool in a variety of research efforts. The atypical saw-tooth profile of the micro stamps enabled a unique degree of control and flexibility over patterned line and gap widths. Cortical neurons cultured on patterned poly-lysine micro-lines on PDMS exhibit a startling transition in axonal guidance: From the expected parallel guidance to an unexpected perpendicular guidance that becomes dominant as patterned lines and gaps become sufficiently narrow. This transition is most obvious when the lines are narrow relative to gaps, while the periodicity of the pattern is reduced. Axons growing perpendicular to micro-lines exhibited 'vinculated' growth, a unique morphological phenotype consisting of periodic orthogonal extensions along the axon.
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Registered trials
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