ArticleMolecular endocrinology (Baltimore, Md.)2013
Nr4a1 is required for fasting-induced down-regulation of Pparγ2 in white adipose tissue.
Article in Molecular endocrinology (Baltimore, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Review
- The Roles of White Adipose Tissue and Liver NADPH in Dietary Restriction-Induced Longevity.Antioxidants (Basel, Switzerland) · 2024Review
- Article
- Nur77 and PPARγ regulate transcription and polarization in distinct subsets of M2-like reparative macrophages during regenerative inflammation.Frontiers in immunology · 2023Article
- Taste 2 Receptor Is Involved in Differentiation of 3T3-L1 Preadipocytes.International journal of molecular sciences · 2022Article
- A nexus of lipid andFrontiers in endocrinology · 2022Review
- Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish.Frontiers in endocrinology · 2022Article
- A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma.Cancer research · 2021Article
- Molecular mechanisms of fat deposition:Archives animal breeding · 2021Article
- Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Integrated Analysis of Tissue-Specific Promoter Methylation and Gene Expression Profile in Complex Diseases.International journal of molecular sciences · 2020Article
- Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes.Frontiers in pharmacology · 2020Review
- The Nuclear Orphan Receptor Nur77 Alleviates Palmitate-induced Fat Accumulation by Down-regulating G0S2 in HepG2 Cells.Scientific reports · 2018Article
- Comparative Transcriptome Profiling of mRNA and lncRNA Related to Tail Adipose Tissues of Sheep.Frontiers in genetics · 2018Article
- The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases.Journal of diabetes research · 2018Review
- Palmitate induces fat accumulation by activating C/EBPβ-mediated G0S2 expression in HepG2 cells.World journal of gastroenterology · 2017Article
- Comparative transcriptome analysis reveals potentially novel roles of Homeobox genes in adipose deposition in fat-tailed sheep.Scientific reports · 2017Article
- The Cytokinome Profile in Patients with Hepatocellular Carcinoma and Type 2 Diabetes.PloS one · 2015Article
- Regulation of NR4A by nutritional status, gender, postnatal development and hormonal deficiency.Scientific reports · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Expression of the nuclear receptor gene, Nur77 (Nr4a1), is induced in white adipose tissue (WAT) in response to β-adrenergic stimulation and fasting. Recently, Nur77 has been shown to play a gene regulatory role in the fasting response of several other major metabolic tissues. Here we investigated the effects of Nur77 on the WAT transcriptome after fasting. For this purpose, we performed gene expression profiling of WAT from wild-type and Nur77(-/-) mice submitted to prolonged fasting. Results revealed Nur77-dependent changes in expression profiles of 135 transcripts, many involved in insulin signaling, lipid and fatty acid metabolism, and glucose metabolism. Network analysis identified the deregulated genes Pparγ2 and Nur77 as central hubs and closely connected in the network, indicating overlapping biological function. We further assayed the expression level of Pparγ2 in a bigger cohort of fasted mice and found a significant Nur77-dependent down-regulation of Pparγ2 in the wild-type mice (P = 0.021, n = 10). Consistently, the expression of several known Pparγ2 targets, found among the Nur77-regulated genes (i.e. G0s2, Grp81, Fabp4, and Adipoq), were up-regulated in WAT of fasted Nur77(-/-) mice. Finally, we show with chromatin immunoprecipitation and luciferase assays that the Pparγ2 promoter is a direct target of Nurr-related 77-kDa protein (Nur77)-dependent repressive regulation and that the N-terminal domain of Nur77 is required for this regulation. In conclusion, we present data implicating Nur77 as a mediator of fasting-induced Pparγ2 regulation in WAT.
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