ArticleNature communications2012
CRT1 is a nuclear-translocated MORC endonuclease that participates in multiple levels of plant immunity.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- The complex immune puzzle: A deeper dive into the MORC1-mediated broad-spectrum defense signaling pathway.The Plant cell · 2025Article
- The kinase CPK5 phosphorylates MICRORCHIDIA1 to promote broad-spectrum disease resistance.The Plant cell · 2025Article
- ThemSphere · 2024Article
- AeLife · 2024Article
- Arabidopsis MORC1 and MED9 Interact to Regulate Defense Gene Expression and Plant Fitness.The plant pathology journal · 2024Article
- DNA sequence and chromatin differentiate sequence-specific transcription factor binding in the human malaria parasite Plasmodium falciparum.Nucleic acids research · 2024Article
- Shared and Related Molecular Targets and Actions of Salicylic Acid in Plants and Humans.Cells · 2023Review
- Whole-genome resequencing of wild and cultivated cannabis reveals the genetic structure and adaptive selection of important traits.BMC plant biology · 2022Article
- Genome-Wide Associations with Resistance to Bipolaris Leaf Spot (Plants (Basel, Switzerland) · 2022Article
- CRISPR/SpCas9-mediated double knockout of barley Microrchidia MORC1 and MORC6a reveals their strong involvement in plant immunity, transcriptional gene silencing and plant growth.Plant biotechnology journal · 2022Article
- Multifaceted roles of RNA polymerase IV in plant growth and development.Journal of experimental botany · 2020Article
- The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis.Nature communications · 2020Article
- Role of Chromatin Architecture in Plant Stress Responses: An Update.Frontiers in plant science · 2020Review
- Perspectives on intracellular perception of plant viruses.Molecular plant pathology · 2019Review
- The Gene-Silencing Protein MORC-1 Topologically Entraps DNA and Forms Multimeric Assemblies to Cause DNA Compaction.Molecular cell · 2019Article
- Chromatin Evolution-Key Innovations Underpinning Morphological Complexity.Frontiers in plant science · 2019Review
- Further analysis of barley MORC1 using a highly efficient RNA-guided Cas9 gene-editing system.Plant biotechnology journal · 2018Article
- MORC Domain Definition and Evolutionary Analysis of the MORC Gene Family in Green Plants.Genome biology and evolution · 2018Article
- Differential Regulation of Two-Tiered Plant Immunity and Sexual Reproduction by ANXUR Receptor-Like Kinases.The Plant cell · 2017Article
- MORC Proteins: Novel Players in Plant and Animal Health.Frontiers in plant science · 2017Review
Corrections and comments
- Erratum issuedMang, Hyong-Gon [corrected to Mang, Hyung-Gon]
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arabidopsis thaliana CRT1 (compromised for recognition of Turnip Crinkle Virus) was previously shown to be required for effector-triggered immunity. Sequence analyses previously revealed that CRT1 contains the ATPase and S5 domains characteristic of Microchidia (MORC) proteins; these proteins are associated with DNA modification and repair. Here we show that CRT1 and its closest homologue, CRH1, are also required for pathogen-associated molecular pattern (PAMP)-triggered immunity, basal resistance, non-host resistance and systemic acquired resistance. Consistent with its role in PAMP-triggered immunity, CRT1 interacted with the PAMP recognition receptor FLS2. Subcellular fractionation and transmission electron microscopy detected a subpopulation of CRT1 in the nucleus, whose levels increased following PAMP treatment or infection with an avirulent pathogen. These results, combined with the demonstration that CRT1 binds DNA, exhibits endonuclease activity, and affects tolerance to the DNA-damaging agent mitomycin C, argue that this prototypic eukaryotic member of the MORC superfamily has important nuclear functions during immune response activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.