ArticleDevelopment (Cambridge, England)2013
Fgf signaling governs cell fate in the zebrafish pineal complex.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Fold-and-fuse neurulation in zebrafish requires vangl2.Developmental biology · 2025Article
- Zebrafish Dark-Dependent Behavior Requires Phototransduction by the Pineal Gland.Journal of pineal research · 2024Article
- Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior.Journal of pineal research · 2022Article
- Ontogenesis of the asymmetric parapineal organ in the zebrafish epithalamus.Frontiers in cell and developmental biology · 2022Article
- Conserved and diverged asymmetric gene expression in the brain of teleosts.Frontiers in cell and developmental biology · 2022Article
- Brain and Behavioral Asymmetry: A Lesson From Fish.Frontiers in neuroanatomy · 2020Review
- Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration.eLife · 2019Article
- Article
- A Notch-mediated, temporal asymmetry in BMP pathway activation promotes photoreceptor subtype diversification.PLoS biology · 2019Article
- Left/right asymmetric collective migration of parapineal cells is mediated by focal FGF signaling activity in leading cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Development and connectivity of the habenular nuclei.Seminars in cell & developmental biology · 2018Review
- Foxg1 deletion impairs the development of the epithalamus.Molecular brain · 2018Article
- Novel hypophysiotropic AgRP2 neurons and pineal cells revealed by BAC transgenesis in zebrafish.Scientific reports · 2017Article
- A transcription factor network controls cell migration and fate decisions in the developing zebrafish pineal complex.Development (Cambridge, England) · 2016Article
- Identification of differentially expressed genes during development of the zebrafish pineal complex using RNA sequencing.Developmental biology · 2014Article
- Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus.Neural development · 2014Article
- Pitx2c ensures habenular asymmetry by restricting parapineal cell number.Development (Cambridge, England) · 2014Article
- FGF signaling is required for brain left-right asymmetry and brain midline formation.Developmental biology · 2014Article
- Article
- Laminin β1a controls distinct steps during the establishment of digestive organ laterality.Development (Cambridge, England) · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Left-right (L-R) asymmetries in neuroanatomy exist throughout the animal kingdom, with implications for function and behavior. The molecular mechanisms that control formation of such asymmetries are beginning to be understood. Significant progress has been made by studying the zebrafish parapineal organ, a group of neurons on the left side of the epithalamus. Parapineal cells arise from the medially located pineal complex anlage and migrate to the left side of the brain. We have found that Fgf8a regulates a fate decision among anterior pineal complex progenitors that occurs just prior to the initiation of leftward migration. Cell fate analysis shows that in the absence of Fgf8a a subset of cells in the anterior pineal complex anlage differentiate as cone photoreceptors rather than parapineal neurons. Fgf8a acts permissively to promote parapineal fate in conjunction with the transcription factor Tbx2b, but might also block cone photoreceptor fate. We conclude that this subset of anterior pineal complex precursors, which normally become parapineal cells, are bipotential and require Fgf8a to maintain parapineal identity and/or prevent cone identity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.