ArticleHuman vaccines & immunotherapeutics2013
Identification and characterization of antigens as vaccine candidates against Klebsiella pneumoniae.
Article in Human vaccines & immunotherapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Variable progressive behavior ofFrontiers in immunology · 2026Article
- The development of functional opsonophagocytic assays to evaluate antibody responses tomSphere · 2025Article
- Exploring current hypervirulentFrontiers in microbiology · 2025Review
- Co-immunization with DNA vaccines encoding yidR and IL-17 augments host immune response againstVirulence · 2024Article
- A new multi-epitope DNA vaccine against Helicobacter Pylori infection in a BALB/c mouse model.Heliyon · 2024Article
- Deep Intraclonal Analysis for the Development of Vaccines against Drug-ResistantInternational journal of molecular sciences · 2024Article
- Oral administration of Lactobacillus plantarum expressing aCD11c modulates cellular immunity alleviating inflammatory injury due to Klebsiella pneumoniae infection.BMC veterinary research · 2024Article
- Integration of immunoinformatics and cheminformatics to design and evaluate a multitope vaccine againstFrontiers in molecular biosciences · 2023Article
- Immunogenic characteristics of the outer membrane phosphoporin as a vaccine candidate against Klebsiella pneumoniae.Veterinary research · 2022Article
- Secondary Complement Deficiency Impairs Anti-Microbial Immunity toFrontiers in immunology · 2022Article
- Current Stage in the Development of Klebsiella pneumoniae Vaccines.Infectious diseases and therapy · 2021Review
- Article
- A Novel Design of Multi-epitope Vaccine AgainstInternational journal of peptide research and therapeutics · 2021Article
- Identification and Evaluation of Recombinant Outer Membrane Proteins as Vaccine Candidates AgainstFrontiers in immunology · 2021Article
- Clinical Epidemiology, Risk Factors, and Control Strategies ofFrontiers in microbiology · 2021Review
- Design and Characterization of a Novel Tool for the Antigenic Enrichment ofPathogens (Basel, Switzerland) · 2020Article
- A murine model demonstrates capsule-independent adaptive immune protection in survivors ofDisease models & mechanisms · 2020Article
- The Diversity of Lipopolysaccharide (O) and Capsular Polysaccharide (K) Antigens of InvasiveFrontiers in microbiology · 2020Article
- Immunoinformatics-Aided Design and Evaluation of a Potential Multi-Epitope Vaccine againstVaccines · 2019Article
- Progress towards the development of Klebsiella vaccines.Expert review of vaccines · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nosocomial infections, also called "hospital acquired infections," occur worldwide and affect both developed and resource-poor countries, thus having a major impact on their health care systems. Klebsiella pneumoniae, which is an opportunistic Gram-negative pathogen, is responsible for causing pneumonia, urinary tract infections and septicemia in immune compromised hosts such as neonates. Unfortunately, there is no vaccine or mAb available for prophylactic or therapeutic use against K. pneumoniae infections. For this reason, we sought for a protein-based subunit vaccine capable of combating K. pneumoniae infections, by applying our ANTIGENome technology for the identification of potential vaccine candidates, focusing on conserved protein antigens present in strains with different serotypes. We identified numerous novel immunogenic proteins using genomic surface display libraries and human serum antibodies from donors exposed to or infected by K. pneumoniae. Vaccine candidate antigens were finally selected based on animal protection in a murine lethal-sepsis model. The protective and highly conserved antigens identified in this study are promising candidates for the development of a protein-based vaccine to prevent infection by K. pneumoniae.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.