ArticleAnesthesiology2013
Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin.
Article in Anesthesiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 72 citations in OpenAlex.
- Persistent Postpartum Pain - A Somatic and Psychologic Perfect Storm.Journal of pain research · 2024Review
- Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats.Communications biology · 2022Article
- Persistent pain after childbirth.BJA education · 2022Review
- Mechanisms Underlying Lumbopelvic Pain During Pregnancy: A Proposed Model.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Development of Magnetic Nanobeads Modified by Artificial Fluorescent Peptides for the Highly Sensitive and Selective Analysis of Oxytocin.Sensors (Basel, Switzerland) · 2020Article
- Downregulation of microRNA‑29c reduces pain after child delivery by activating the oxytocin‑GABA pathway.Molecular medicine reports · 2020Article
- Factors associated with persistent pain after childbirth: a narrative review.British journal of anaesthesia · 2020Review
- Intrathecal Oxytocin Improves Spontaneous Behavior and Reduces Mechanical Hypersensitivity in a Rat Model of Postoperative Pain.Frontiers in pharmacology · 2020Article
- Article
- Capsaicin-induced pain and sensitisation in the postpartum period.British journal of anaesthesia · 2019Article
- Plasticity and Function of Spinal Oxytocin and Vasopressin Signaling during Recovery from Surgery with Nerve Injury.Anesthesiology · 2018Article
- Chronic pain during pregnancy: a review of the literature.International journal of women's health · 2018Review
- Oxytocin Relieves Neuropathic Pain Through GABA Release and Presynaptic TRPV1 Inhibition in Spinal Cord.Frontiers in molecular neuroscience · 2018Article
- Pituitary Hormones and Orofacial Pain.Frontiers in integrative neuroscience · 2018Article
- Disruption of Spinal Noradrenergic Activation Delays Recovery of Acute Incision-Induced Hypersensitivity and Increases Spinal Glial Activation in the Rat.The journal of pain · 2016Article
- Intranasal Oxytocin Administration is Associated With Enhanced Endogenous Pain Inhibition and Reduced Negative Mood States.The Clinical journal of pain · 2015Article
- Phase 1 safety assessment of intrathecal oxytocin.Anesthesiology · 2015Article
- Oxytocin - a multifunctional analgesic for chronic deep tissue pain.Current pharmaceutical design · 2015Review
- Modeling individual recovery after peripheral nerve injury in rats and the effects of parturition.Anesthesiology · 2014Article
- Preclinical toxicity screening of intrathecal oxytocin in rats and dogs.Anesthesiology · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPhysical injury, including surgery, can result in chronic pain; yet chronic pain following childbirth, including cesarean delivery in women, is rare. The mechanisms involved in this protection by pregnancy or delivery have not been explored.
methodsWe examined the effect of pregnancy and delivery on hypersensitivity to mechanical stimuli of the rat hindpaw induced by peripheral nerve injury (spinal nerve ligation) and after intrathecal oxytocin, atosiban, and naloxone. Additionally, oxytocin concentration in lumbar spinal cerebrospinal fluid was determined.
resultsSpinal nerve ligation performed at mid-pregnancy resulted in similar hypersensitivity to nonpregnant controls, but hypersensitivity partially resolved beginning after delivery. Removal of pups after delivery prevented this partial resolution. Cerebrospinal fluid concentrations of oxytocin were greater in normal postpartum rats prior to weaning. To examine the effect of injury at the time of delivery rather than during pregnancy, spinal nerve ligation was performed within 24 h of delivery. This resulted in acute hypersensitivity that partially resolved over the next 2-3 weeks. Weaning of pups resulted only in a temporary return of hypersensitivity. Intrathecal oxytocin effectively reversed the hypersensitivity following separation of the pups. Postpartum resolution of hypersensitivity was transiently abolished by intrathecal injection of the oxytocin receptor antagonist, atosiban.
conclusionsThese results suggest that the postpartum period rather than pregnancy protects against chronic hypersensitivity from peripheral nerve injury and that this protection may reflect sustained oxytocin signaling in the central nervous system during this period.
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