ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
Associations between TCF4 gene polymorphism and cognitive functions in schizophrenia patients and healthy controls.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders.Molecular psychiatry · 2018Pooled it
- Overlap between genetic variants associated with schizophrenia spectrum disorders and intelligence quotient: a systematic review.Journal of psychiatry & neuroscience : JPNPooled it
- Transcription factor 4 and its association with psychiatric disorders.Translational psychiatry · 2021Review
- Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data.Translational psychiatry · 2020Article
- Genetic Variability of TCF4 in Schizophrenia of Southern Chinese Han Population: A Case-Control Study.Frontiers in genetics · 2019Article
- TCF4 and GRM8 gene polymorphisms and risk of schizophrenia in an Iranian population: a case-control study.Molecular biology reports · 2018Article
- The integrated landscape of causal genes and pathways in schizophrenia.Translational psychiatry · 2018Article
- The schizophrenia- and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner.Molecular psychiatry · 2018Article
- Molecular Mechanisms of Transcription Factor 4 in Pitt Hopkins Syndrome.Current genetic medicine reports · 2017Article
- Relationship between hippocampal subfield volumes and memory deficits in patients with thalamus infarction.European archives of psychiatry and clinical neuroscience · 2016Article
- Article
- The neural circuitry supporting goal maintenance during cognitive control: a comparison of expectancy AX-CPT and dot probe expectancy paradigms.Cognitive, affective & behavioral neuroscience · 2016Article
- Neurodevelopmental models of transcription factor 4 deficiency converge on a common ion channel as a potential therapeutic target for Pitt Hopkins syndrome.Rare diseases (Austin, Tex.) · 2016Article
- Evidence for the contribution of NOS1 gene polymorphism (rs3782206) to prefrontal function in schizophrenia patients and healthy controls.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective.Cellular and molecular life sciences : CMLS · 2014Review
- Association of a risk allele of ANK3 with cognitive performance and cortical thickness in patients with first-episode psychosis.Journal of psychiatry & neuroscience : JPN · 2014Article
- Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex.Journal of psychiatric research · 2013Article
- Neurodevelopment in schizophrenia: the role of the wnt pathways.Current neuropharmacology · 2013Article
- Article
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Authors and funding
16 authors.
Funding
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Abstract
The SNP rs2958182 was reported to be significantly associated with schizophrenia (SCZ) in Han Chinese. This study examined this SNP's associations with cognitive functions in 580 SCZ patients and 498 controls. Cognitive functions were assessed using the Wechsler Adult Intelligence Scale-Revised (WAIS-RC), the Attention Network Task (ANT), the Stroop task, the dot pattern expectancy (DPX), task and the N-back working memory task. Results showed significant or marginally significant interaction effects between genotype and diagnosis status on IQ (P=0.011) and attention-related tasks (ie, the forward digit span of WAIS-RC, P=0.005; the ANT conflict effect; P=0.020, and its ratios over mean reaction time (RT), P=0.036; the Stroop conflict effect, P=0.032, and its ratios over mean RT, P=0.062; and the DPX task's error rate under the BX condition, P<0.001, and the error rate of BX minus the error rate of AY (BX-AY), P=0.002). There were no such interaction effects on the measures of working memory (all P-values >0.05). Further analysis of the significant genotype-by-diagnosis interactions showed that the risk (T) allele was associated with better performance on cognitive tasks in patients but with worse performance in controls. These results seem to indicate that the association between this SNP and selected cognitive functions may be of an inverted U-shaped pattern. Future research is needed to replicate these results and to explore the biochemical mechanisms behind this association.
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