ArticleAmerican journal of physiology. Endocrinology and metabolism2013
Thermoneutrality modifies the impact of hypoxia on lipid metabolism.
Article in American journal of physiology. Endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- The effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial.Journal of translational medicine · 2021Trial
- Intermittent Hypoxia as a Model of Obstructive Sleep Apnea: Present and Future.Sleep medicine clinics · 2025Review
- Thermoneutrality Inhibits Thermogenic Markers and Exacerbates Nonalcoholic Fatty Liver Disease in Mice.International journal of molecular sciences · 2024Article
- Senolytic Therapy in Sleep Apnea: Murky Waters or Fountain of Youth?American journal of respiratory and critical care medicine · 2024Article
- Experimental Models to Study End-Organ Morbidity in Sleep Apnea: Lessons Learned and Future Directions.International journal of molecular sciences · 2022Review
- An Inexpensive Open-Source Chamber for Controlled Hypoxia/Hyperoxia Exposure.Frontiers in physiology · 2022Article
- Cholesterol metabolism and brain injury in neonatal encephalopathy.Pediatric research · 2021Review
- Physiological Responses to Hypoxia on Triglyceride Levels.Frontiers in physiology · 2021Review
- HIF-1α as a Mediator of Insulin Resistance, T2DM, and Its Complications: Potential Links With Obstructive Sleep Apnea.Frontiers in physiology · 2020Review
- Thermoneutrality and Immunity: How Does Cold Stress Affect Disease?Frontiers in immunology · 2020Review
- Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing.Journal of visualized experiments : JoVE · 2019Article
- The Effect of Acute Continuous Hypoxia on Triglyceride Levels in Constantly Fed Healthy Men.Frontiers in physiology · 2019Article
- Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response.The Journal of physiology · 2019Article
- Does Hypoxia Decrease the Metabolic Rate?Frontiers in endocrinology · 2018Review
- Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis.Journal of molecular medicine (Berlin, Germany) · 2017Article
- Biological plausibility linking sleep apnoea and metabolic dysfunction.Nature reviews. Endocrinology · 2016Review
- Thermoneutrality decreases thermogenic program and promotes adiposity in high-fat diet-fed mice.Physiological reports · 2016Article
- Sleep Apnea Research in Animals. Past, Present, and Future.American journal of respiratory cell and molecular biology · 2016Review
- Article
- Metabolic dysfunction in obstructive sleep apnea: A critical examination of underlying mechanisms.Sleep and biological rhythms · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Hypoxia has been shown to rapidly increase triglycerides in mice by decreasing plasma lipoprotein clearance. However, the usual temperature of hypoxic exposure is below thermoneutrality for mice, which may increase thermogenesis and energy requirements, resulting in higher tissue lipid uptake. We hypothesize that decreased lipid clearance and ensuing hyperlipidemia are caused by hypoxic suppression of metabolism at cold temperatures and, therefore, would not occur at thermoneutrality. Twelve-week-old, male C57BL6/J mice were exposed to 6 h of 10% O₂ at the usual temperature (22°C) or thermoneutrality (30°C). Acclimation to 22°C increased lipid uptake in the heart, lungs, and brown adipose tissue, resulting in lower plasma triglyceride and cholesterol levels. At this temperature, hypoxia attenuated lipid uptake in most tissues, thereby raising plasma triglycerides and LDL cholesterol. Thermoneutrality decreased tissue lipid uptake, and hypoxia did not cause a further reduction in lipid uptake in any organs. Consequently, hypoxia at thermoneutrality did not affect plasma triglyceride levels. Unexpectedly, plasma HDL cholesterol increased. The effect of hypoxia on white adipose tissue lipolysis was also modified by temperature. Independent of temperature, hypoxia increased heart rate and glucose and decreased activity, body temperature, and glucose sensitivity. Our study underscores the importance of ambient temperature for hypoxia research, especially in studies of lipid metabolism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.