ArticleEpigenetics2013
The epigenome of AML stem and progenitor cells.
Article in Epigenetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed.
- Properties of Leukemic Stem Cells in Regulating Drug Resistance in Acute and Chronic Myeloid Leukemias.Biomedicines · 2022Review
- Review
- Epigenetic regulation of cancer stem cell formation and maintenance.International journal of cancer · 2021Review
- The DNA methylation landscape of hematological malignancies: an update.Molecular oncology · 2020Review
- Review
- Stem-Like Signature Predicting Disease Progression in Early Stage Bladder Cancer. The Role of E2F3 and SOX4.Biomedicines · 2018Review
- Molecular and epigenetic regulatory mechanisms of normal stem cell radiosensitivity.Cell death discovery · 2018Review
- Polyamine flux suppresses histone lysine demethylases and enhancesCell death discovery · 2018Article
- Cancer stem cells and tumorigenesis.Biophysics reports · 2018Review
- Review
- Large-scale gene network analysis reveals the significance of extracellular matrix pathway and homeobox genes in acute myeloid leukemia: an introduction to the Pigengene package and its applications.BMC medical genomics · 2017Article
- Novel strategies for targeting leukemia stem cells: sounding the death knell for blood cancer.Cellular oncology (Dordrecht, Netherlands) · 2017Review
- Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment.Acta pharmacologica Sinica · 2015Review
- Article
- Digging deep into "dirty" drugs - modulation of the methylation machinery.Drug metabolism reviews · 2015Review
- Endoplasmic reticulum stress, genome damage, and cancer.Frontiers in oncology · 2015Review
- Exposure to low-dose (56)Fe-ion radiation induces long-term epigenetic alterations in mouse bone marrow hematopoietic progenitor and stem cells.Radiation research · 2014Article
- Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance.Molecular cell · 2014Review
- Age-related epigenetic drift in the pathogenesis of MDS and AML.Genome research · 2014Article
- Concise review: Leukemia stem cells in personalized medicine.Stem cells (Dayton, Ohio) · 2014Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Acute myeloid leukemia (AML) is sustained by a population of cancer stem cells (CSCs or cancer-initiating cell). The mechanisms underlying switches from CSCs to non-CSCs in vivo remain to be understood. We address this issue in AML from the aspect of epigenetics using genome-wide screening for DNA methylation and selected histone modifications. We found no major differences in DNA methylation, especially in promoter CpG islands, between CSCs and non-CSCs. By contrast, we found thousands of genes that change H3K4me3 and/or H3K27me3 status between stem and progenitor cells as well as between progenitor and mature cells. Stem cell related pathways and proliferation or metabolism related pathways characterize genes differentially enriched for H3K4me3/H3K27me3 in stem and progenitor populations. Bivalent genes in stem cells are more plastic during differentiation and are more likely to lose H3K4me3 than to lose H3K27me3, consistent with increasingly closed chromatin state with differentiation. Our data indicates that histone modifications but not promoter DNA methylation are involved in switches from CSCs to non-CSCs in AML.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.