ReviewReports on progress in physics. Physical Society (Great Britain)2013
Single-molecule nanometry for biological physics.
Review in Reports on progress in physics. Physical Society (Great Britain), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Dynamic positioning of Rpc34 winged helix in RNA polymerase III elongation complex for its stability with implications for reinitiation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Recent Advance in Single-Molecule Fluorescent Biosensors for Tumor Biomarker Detection.Biosensors · 2024Review
- Single-molecule biophysics experimentsiScience · 2022Article
- Regeneration of PEG slide for multiple rounds of single-molecule measurements.Biophysical journal · 2021Article
- Single-Molecule FRET Detection of Sub-Nanometer Distance Changes in the Range below a 3-Nanometer Scale.Biosensors · 2020Article
- Single-Molecule Mechanics in Ligand Concentration Gradient.Micromachines · 2020Article
- Site-Specific Three-Color Labeling of α-Synuclein via Conjugation to Uniquely Reactive Cysteines during Assembly by Native Chemical Ligation.Cell chemical biology · 2018Article
- Article
- Distinguishing Signatures of Multipathway Conformational Transitions.Physical review letters · 2017Article
- High-Resolution Optical Tweezers Combined With Single-Molecule Confocal Microscopy.Methods in enzymology · 2017Article
- Improved Glass Surface Passivation for Single-Molecule Nanoarrays.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- Dual Unnatural Amino Acid Incorporation and Click-Chemistry Labeling to Enable Single-Molecule FRET Studies of p97 Folding.Chembiochem : a European journal of chemical biology · 2016Article
- Testing a proposed paradigm shift in analysis of phage DNA packaging.Bacteriophage · 2016Article
- Subangstrom single-molecule measurements of motor proteins using a nanopore.Nature biotechnology · 2015Article
- An improved surface passivation method for single-molecule studies.Nature methods · 2014Article
- High-throughput single-molecule studies of protein-DNA interactions.FEBS letters · 2014Review
- The bright future of single-molecule fluorescence imaging.Current opinion in chemical biology · 2014Review
- Studying DNA-protein interactions with single-molecule Förster resonance energy transfer.Protoplasma · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Precision measurement is a hallmark of physics but the small length scale (∼nanometer) of elementary biological components and thermal fluctuations surrounding them challenge our ability to visualize their action. Here, we highlight the recent developments in single-molecule nanometry where the position of a single fluorescent molecule can be determined with nanometer precision, reaching the limit imposed by the shot noise, and the relative motion between two molecules can be determined with ∼0.3 nm precision at ∼1 ms time resolution, as well as how these new tools are providing fundamental insights into how motor proteins move on cellular highways. We will also discuss how interactions between three and four fluorescent molecules can be used to measure three and six coordinates, respectively, allowing us to correlate the movements of multiple components. Finally, we will discuss recent progress in combining angstrom-precision optical tweezers with single-molecule fluorescent detection, opening new windows for multi-dimensional single-molecule nanometry for biological physics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.