Evidence map›Paper›PMID 23249562›Full record

ArticleBMC medical informatics and decision making2012

The R0 package: a toolbox to estimate reproduction numbers for epidemic outbreaks.

Thomas Obadia, Romana Haneef, Pierre-Yves Boëlle

Abstract read
In one paragraph

Article in BMC medical informatics and decision making, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

145 citing papers in PubMed.

  1. Hidden Burden of a Measles Outbreak Revealed by Genomic and Transmission Models.medRxiv : the preprint server for health sciences · 2026
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  4. A mobility-adjusted framework for regional RBMC infectious diseases · 2025
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  6. Transmission Dynamics of Mpox in Peru During the 2022 Outbreak.The American journal of tropical medicine and hygiene · 2025
    Article
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85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thomas ObadiaINSERM, U707, Paris, France.
Romana Haneef
Pierre-Yves Boëlle

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral generic methods have been proposed to estimate transmission parameters during an outbreak, especially the reproduction number. However, as of today, no dedicated software exists that implements these methods and allow comparisons.

resultsA review of generic methods used to estimate transmissibility parameters during outbreaks was carried out. Most methods used the epidemic curve and the generation time distribution. Two categories of methods were available: those estimating the initial reproduction number, and those estimating a time dependent reproduction number. We implemented five methods as an R library, developed sensitivity analysis tools for each method and provided numerical illustrations of their use. A comparison of the performance of the different methods on simulated datasets is reported.

conclusionsThis software package allows a standardized and extensible approach to the estimation of the reproduction number and generation interval distribution from epidemic curves.

Indexed as

Basic Reproduction NumberDisease OutbreaksDisease Transmission, InfectiousBiasConfidence IntervalsHumansModels, StatisticalSoftware

Identifiers

PMID23249562
PMCPMC3582628

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.