ReviewAntioxidants & redox signaling2013
Manganese complexes: diverse metabolic routes to oxidative stress resistance in prokaryotes and yeast.
Review in Antioxidants & redox signaling, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
91 citing papers in PubMed, 1 synthesis or guideline pooled it, 158 citations in OpenAlex.
- Oxidative stress tolerance and antioxidant capacity of lactic acid bacteria as probiotic: a systematic review.Gut microbes · 2020Pooled it
- pH-dependent allosteric remodeling of a bacterial riboswitch couples alkaline activation to metal sensing.Nucleic acids research · 2026Article
- Integrated GC-HRAM-MS and UHPLC-QTOF-MS metabolomics reveal mineral-induced metabolic adaptation ofFood chemistry: X · 2026Article
- DrPitA-mediated enrichment of intracellular manganese and phosphate contributes to oxidative stress resistance ofApplied and environmental microbiology · 2026Article
- Aroma Profile of Worts and Contents of Selected Mineral Elements in Brewing with Malted and Unmalted Hemp Seeds.Molecules (Basel, Switzerland) · 2026Article
- Life resists chemistry not conditions.FEMS microbes · 2026Article
- Evaluating the scientific and regulatory case for the deployment of the radioresistant genusFrontiers in microbiology · 2026Review
- Haloferax mediterranei R4 for bioremediation of desalination and textile wastes: a step towards their valorisation.Applied microbiology and biotechnology · 2025Article
- Manganese-engineered Lactobacillus Reuteri with enhanced antitumor and immunomodulatory activities for colorectal cancer prevention and treatment.Nature communications · 2025Article
- Article
- Structural switches: intracellular G-quadruplexes modulate DNA repair and genome maintenance inmBio · 2025Article
- Historical Land Use Drives Present Microbial Community Assembly in an Extreme Environment.Environmental microbiology · 2025Article
- The Role of the MntABC Transporter System in the Oxidative Stress Resistance ofInternational journal of molecular sciences · 2025Article
- Evolution of cross-tolerance to metals in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Role of manganese in brain health and disease: Focus on oxidative stress.Free radical biology & medicine · 2025Review
- Surviving the storm: exploring the role of natural transformation in nutrition and DNA repair of stressedApplied and environmental microbiology · 2025Article
- Prophylactically Feeding Manganese toAntioxidants (Basel, Switzerland) · 2025Article
- Metals in Motion: Understanding Labile Metal Pools in Bacteria.Biochemistry · 2025Review
- Antimicrobial and scavenging potential of green synthesized silver/manganese bimetallic nanoparticles usingPeerJ · 2025Article
- The ternary complex of MnProceedings of the National Academy of Sciences of the United States of America · 2024Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
significanceAntioxidant enzymes are thought to provide critical protection to cells against reactive oxygen species (ROS). However, many organisms can fully compensate for the loss of such enzymatic defenses by accumulating metabolites and Mn²⁺, which can form catalytic Mn-antioxidants. Accumulated metabolites can direct reactivity of Mn²⁺ with superoxide and specifically shield proteins from oxidative damage. RECENT ADVANCES: There is mounting evidence that Mn-Pi (orthophosphate) complexes act as potent scavengers of superoxide in all three branches of life. Moreover, it is evident that Mn²⁺ in complexes with carbonates, peptides, nucleosides, and organic acids can also form catalytic Mn-antioxidants, pointing to diverse metabolic routes to oxidative stress resistance. CRITICAL ISSUES: What conditions favor utility of Mn-metabolites versus enzymatic means for removing ROS? Mn²⁺-metabolite defenses are critical for preserving the activity of repair enzymes in Deinococcus radiodurans exposed to intense radiation stress, and in Lactobacillus plantarum, which lacks antioxidant enzymes. In other microorganisms, Mn-antioxidants can serve as an auxiliary protection when enzymatic antioxidants are insufficient or fail. These findings of a critical role of Mn-antioxidants in the survival of prokaryotes under oxidative stress parallel the trends developing for the simple eukaryote Saccharomyces cerevisiae. FUTURE DIRECTIONS: Phosphates, peptides and organic acids are just a snapshot of the types of anionic metabolites that promote such reactivity of Mn²⁺. Their probable roles in pathogen defense against the host immune response and in ROS-mediated signaling pathways are also areas that are worthy of serious investigation. Moreover, it is clear that these protective chemical processes can be harnessed for practical purposes.
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Registered trials
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