ReviewDNA and cell biology2013
A perspective on the role of extracellular hemoglobin on the innate immune system.
Review in DNA and cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Hepatitis B virus vaccine immune response and mortality in dialysis patients: a meta-analysis.Journal of nephrology · 2020Pooled it
- Erythrocyte-inspired biomaterials for cancer immunotherapy: Integration within the cancer-immunity cycle.Materials today. Bio · 2026Review
- Stage-Specific Proteomic Profiles in Dental Caries.Journal of dental research · 2026Article
- The Predictive Value of Hemoglobin-to-Red Blood Cell Distribution Width Ratio for the Prognosis of Patients with Aortic Dissection: Based on the Medical Information Mart for Intensive Care-IV Database.Anatolian journal of cardiology · 2025Article
- Placental transcriptome analysis in opioid-exposed versus non-opioid exposed pregnancies.Placenta · 2025Article
- Pangolin scales as adaptations for innate immunity against pathogens.BMC biology · 2024Article
- Extracellular Hemoglobin: Modulation of Cellular Functions and Pathophysiological Effects.Biomolecules · 2022Review
- The Oxidative Injury of Extracellular Hemoglobin Is Associated With Reactive Oxygen Species Generation of Grass Carp (Frontiers in immunology · 2022Article
- The Protective Effects of Three Polysaccharides FromFrontiers in veterinary science · 2022Article
- Mechanistic insights into cell-free hemoglobin-induced injury during septic shock.American journal of physiology. Heart and circulatory physiology · 2021Article
- Cell-free oxidized hemoglobin drives reactive oxygen species production and pro-inflammation in an immature primary rat mixed glial cell culture.Journal of neuroinflammation · 2021Article
- Carvacrol, Thymol, and Garlic Essential Oil Promote Skin Innate Immunity in Gilthead Seabream (Frontiers in immunology · 2021Article
- The NLRP3 inflammasome in macrophages is stimulated by cell-free hemoglobin.Physiological reports · 2020Article
- Insights into the Natural Defenses of a Coral Reef Fish Against Gill Ectoparasites: Integrated Metabolome and Microbiome Approach.Metabolites · 2020Article
- The Role of Circulating Cell-Free Hemoglobin in Sepsis-Associated Acute Kidney Injury.Seminars in nephrology · 2020Review
- Sequencing Analysis and Identification of the Primary Peptide Component of the Dialyzable Leukocyte Extract "Transferon Oral": The Starting Point to Understand Its Mechanism of Action.Frontiers in pharmacology · 2020Article
- The heme and radical scavenger αJournal of neuroinflammation · 2019Article
- Cerebellar Exposure to Cell-Free Hemoglobin Following Preterm Intraventricular Hemorrhage: Causal in Cerebellar Damage?Translational stroke research · 2017Article
- Oxidized Hemoglobin Is Antigenic and Immunogenic in Lupus.Frontiers in immunology · 2017Article
- Postinjury Inflammation and Organ Dysfunction.Critical care clinics · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Host cell-derived danger-associated molecular patterns (DAMPs), such as the hemoglobin (Hb) can interact with the innate immune system either directly or through binding to pathogen-associated molecular patterns (PAMPs). Hemolysis occurs under various pathological conditions, leading to hemoglobinemia. In the extracellular environment, the Hb becomes a redox-reactive DAMP molecule. In severe hemolysis, the massive level of extracellular pro-oxidative Hb generates reactive oxygen species (ROS), which perturbs the innate immune homeostasis. The Hb also binds to PAMPs and triggers Toll-like receptor-mediated signal transduction. In this perspective, we review the roles of cell-free Hb in the innate immune system, focusing on the plausible interactions among Hb, pathogens, host cell components, and innate immune cells, all of which remain to be explored with experiential detail.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.