ReviewExpert review of medical devices2012
Polymeric trileaflet prosthetic heart valves: evolution and path to clinical reality.
Review in Expert review of medical devices, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of first-in-human and early phase clinical trials for surgically implantable biological mitral valve substitutes.Journal of cardiothoracic surgery · 2023Pooled it
- From Polymer Structure to Valve Function: A Multiscale Evaluation of Polycarbonate Polyurethanes for Polymeric Mitral Valves.Annals of biomedical engineering · 2026Article
- Parameterized shape optimization of a bi-leaflet heart valved conduit for pediatric applications.Engineering with computers · 2026Article
- Recent advancements in polymeric heart valves: From basic research to clinical trials.Materials today. Bio · 2024Review
- Designing a Novel Asymmetric Transcatheter Aortic Valve for Stenotic Bicuspid Aortic Valves Using Patient-Specific Computational Modeling.Annals of biomedical engineering · 2023Article
- Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart.Cardiovascular research · 2022Article
- Anisotropic elastic behavior of a hydrogel-coated electrospun polyurethane: Suitability for heart valve leaflets.Journal of the mechanical behavior of biomedical materials · 2022Article
- In-Vitro Biocompatibility and Hemocompatibility Study of New PET Copolyesters Intended for Heart Assist Devices.Polymers · 2020Article
- An Insight into the Structural Diversity and Clinical Applicability of Polyurethanes in Biomedicine.Polymers · 2020Review
- In Vitro Durability and Stability Testing of a Novel Polymeric Transcatheter Aortic Valve.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Article
- Article
- Novel Polymeric Valve for Transcatheter Aortic Valve Replacement Applications: In Vitro Hemodynamic Study.Annals of biomedical engineering · 2019Article
- An in vitro evaluation of turbulence after transcatheter aortic valve implantation.The Journal of thoracic and cardiovascular surgery · 2018Article
- Tunable Elastomers with an Antithrombotic Component for Cardiovascular Applications.Advanced healthcare materials · 2018Article
- Prosthetic Aortic Valves: Challenges and Solutions.Frontiers in cardiovascular medicine · 2018Article
- In Vitro Hydrodynamic Assessment of a New Transcatheter Heart Valve Concept (the TRISKELE).Journal of cardiovascular translational research · 2017Article
- Hemodynamic and thrombogenic analysis of a trileaflet polymeric valve using a fluid-structure interaction approach.Journal of biomechanics · 2015Article
- Physical Characterization and Platelet Interactions under Shear Flows of a Novel Thermoset Polyisobutylene-based Co-polymer.ACS applied materials & interfaces · 2015Article
- Current progress in tissue engineering of heart valves: multiscale problems, multiscale solutions.Expert opinion on biological therapy · 2015Review
- A bio-inspired microstructure induced by slow injection moulding of cylindrical block copolymers.Soft matter · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Present prosthetic heart valves, while hemodynamically effective, remain limited by progressive structural deterioration of tissue valves or the burden of chronic anticoagulation for mechanical valves. An idealized valve prosthesis would eliminate these limitations. Polymeric heart valves (PHVs), fabricated from advanced polymeric materials, offer the potential of durability and hemocompatibility. Unfortunately, the clinical realization of PHVs to date has been hampered by findings of in vivo calcification, degradation and thrombosis. Here, the authors review the evolution of PHVs, evaluate the state of the art of this technology and propose a pathway towards clinical reality. In particular, the authors discuss the development of a novel aortic PHV that may be deployed via transcatheter implantation, as well as its optimization via device thrombogenicity emulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.