ArticleThe open ophthalmology journal2012
Diversity of microbial species implicated in keratitis: a review.
Article in The open ophthalmology journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Bacterial profile of ocular infections: a systematic review.BMC ophthalmology · 2017Pooled it
- Adjunctive Therapies for Bacterial Keratitis.Middle East African journal of ophthalmologyPooled it
- A five-year survey of dematiaceous fungi in a tropical hospital reveals potential opportunistic species.PloS one · 2014Trial
- Fungal Keratitis: A Cross-Sectional Study of Corneal Ulcer Cases in a Tertiary Care Hospital in India.Cureus · 2026Article
- Clinical characteristics, treatment, and outcomes of fungal keratitis/endophthalmitis caused byFrontiers in cellular and infection microbiology · 2026Article
- Recovery and regeneration: exploring positive sequelae of keratitis.BMC ophthalmology · 2025Article
- Microbial keratitis in the age of resistance: unlocking the therapeutic potential of phage therapy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Review
- The Ocular Surface Microbiome in Homeostasis and Dysbiosis.Microorganisms · 2025Review
- Alterations in ocular fungal microbiota in patients with fungal keratitis: a comparative study from coastal regions of Eastern China.BMC ophthalmology · 2025Article
- Updates in Diagnostic Imaging for Infectious Keratitis: A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Managing Corneal Infections: Out with the old, in with the new?Antibiotics (Basel, Switzerland) · 2023Review
- Purification, characterization of an entomopathogenic fungal lectin from Purpureocillium lilacinum and its involvement in pathogenesis leading to mycotic keratitis.Archives of microbiology · 2022Article
- The Case for Fungal Keratitis to Be Accepted as a Neglected Tropical Disease.Journal of fungi (Basel, Switzerland) · 2022Review
- Assessing global fungal threats to humans.mLife · 2022Review
- Nanoparticles Loaded Thermoresponsive In Situ Gel for Ocular Antibiotic Delivery against Bacterial Keratitis.Polymers · 2022Article
- Differential Antimicrobial Efficacy of Preservative-Free Contact Lens Disinfection Systems against Common Ocular Pathogens.Microbiology spectrum · 2022Article
- Determination of probability of causative pathogen in infectious keratitis using deep learning algorithm of slit-lamp images.Scientific reports · 2021Article
- Development of a novel micro-bead force spectroscopy approach to measure the ability of a thermo-active polymer to remove bacteria from a corneal model.Scientific reports · 2021Article
- Therapeutic Ophthalmic Lenses: A Review.Pharmaceutics · 2020Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicrobial keratitis is an infectious disease of the cornea characterised by inflammation and is considered an ophthalmic emergency requiring immediate attention. While a variety of pathogenic microbes associated with microbial keratitis have been identified, a comprehensive review identifying the diversity of species has not been completed.
methodsA search of peer-reviewed publications including case reports and research articles reporting microorganims implicated in keratitis was conducted. Search engines including PubMed, Scopus and Web of Science with years ranging from 1950-2012 were used.
results232 different species from 142 genera, representing 80 families were found to be implicated in microbial keratitis. Fungi exhibited the largest diversity with 144 species from 92 genera. In comparison, 77 species of bacteria from 42 genera, 12 species of protozoa from 4 genera and 4 types of virus were identified as the infectious agents. A comparison of their aetiologies shows reports of similarities between genera.
conclusionsThe diversity of microbial species implicated in keratitis has not previously been reported and is considerably greater than suggested by incidence studies. Effective treatment is heavily reliant upon correct identification of the responsible microorganisms. Species identification, the risk factors associated with, and pathogenesis of microbial keratitis will allow the development of improved therapies. This review provides a resource for clinicians and researchers to assist in identification and readily source treatment information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.