ArticleThe open orthopaedics journal2012
Growth factors and stem cells for the management of anterior cruciate ligament tears.
Article in The open orthopaedics journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- All-inside technique for isolated posterior cruciate ligament tears: Surgical technique and outcomes.Journal of orthopaedics · 2025Article
- Arthroscopic Primary Repair of Proximal Anterior Cruciate Ligament Tears Using a Continuous Bundle Suture Technique With Simplified Suture Passing.Arthroscopy techniques · 2024Article
- Strategies to promote tendon-bone healing after anterior cruciate ligament reconstruction: Present and future.Frontiers in bioengineering and biotechnology · 2023Review
- Feasibility of Growth Factor Agent Therapy in Repairing Motor Injury.Frontiers in pharmacology · 2022Review
- Outcomes of human umbilical cord blood-derived mesenchymal stem cells in enhancing tendon-graft healing in anterior cruciate ligament reconstruction: an exploratory study.Knee surgery & related research · 2021Article
- Improved Short-Term Outcomes of Osteochondral Lesions of the Knee Following Arthroscopic Treatment With Bone Marrow Aspirate Concentrate and Cartilage-Derived Matrix.Arthroscopy, sports medicine, and rehabilitation · 2021Article
- Anterior cruciate ligament reconstruction in a rabbit model using a silk-collagen scaffold modified by hydroxyapatite at both ends: a histological and biomechanical study.Journal of orthopaedic surgery and research · 2021Article
- Percutaneous Anterior Cruciate Ligament Repair With Needle Arthroscopy and Biological Augmentation.Arthroscopy techniques · 2021Article
- Arthroscopic Chondral Defect Repair With Extracellular Matrix Scaffold and Bone Marrow Aspirate Concentrate.Arthroscopy techniques · 2020Article
- Anatomic ligament consolidation of the superior acromioclavicular ligament and the coracoclavicular ligament complex after acute arthroscopically assisted double coracoclavicular bundle stabilization.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Article
- Symptomatic anterior cruciate ligament tears treated with percutaneous injection of autologous bone marrow concentrate and platelet products: a non-controlled registry study.Journal of translational medicine · 2018Article
- Anterior cruciate ligament tears treated with percutaneous injection of autologous bone marrow nucleated cells: a case series.Journal of pain research · 2015Article
- Platelet rich plasma and knee surgery.BioMed research international · 2014Review
- Double bundle anterior cruciate ligament reconstruction: Failure rate and patients-reported outcomes at 4-11 years of follow up.Journal of orthopaedicsArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anterior cruciate ligament (ACL) is fundamental for the knee joint stability. ACL tears are frequent, especially during sport activities, occurring mainly in young and active patients. Nowadays, the gold standard for the management of ACL tears remains the surgical reconstruction with autografts or allografts. New strategies are being developed to resolve the problems of ligament grafting and promote a physiological healing process of ligamentous tissue without requiring surgical reconstruction. Moreover, these strategies can be applicable in association surgical reconstruction and may be useful to promote and accelerate the healing process. The use of growth factors and stem cells seems to offer a new and fascinating solution for the management of ACL tears. The injection of stem cell and/or growth factors in the site of ligamentous injury can potentially enhance the repair process of the physiological tissue. These procedures are still at their infancy, and more in vivo and in vitro studies are required to clarify the molecular pathways and effectiveness of growth factors and stem cells therapy for the management of ACL tears. This review aims to summarize the current knowledge in the field of growth factors and stem cells for the management of ACL tears.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.